Effects of Ningxin Shugan Decoction Combined with Antagonist Fixation Regimen on IVF-ET Outcomes and Serum Kisspeptin Expression in Infertility Patients with Polycystic Ovary Syndrome
10.13422/j.cnki.syfjx.20250194
- VernacularTitle:宁心疏肝汤联合拮抗剂固定方案对多囊卵巢综合征不孕患者IVF-ET结局及血清神经肽吻素表达影响
- Author:
Hua FENG
1
;
Dan XU
2
;
Xuelan HONG
3
Author Information
1. Jiangsu Medical College，Yancheng 224005，China
2. Yancheng No.1 People's Hospital，Yancheng 224006，China
3. Yancheng Affiliated Hospital of Nanjing University of Chinese Medicine，Yancheng 224001，China
- Publication Type:Journal Article
- Keywords:
Ningxin Shugan decoction;
antagonist fixation scheme;
assisted reproduction;
infertility associated with polycystic ovary syndrome;
outcome of in vitro fertilization and embryo transfer （IVF-ET）;
serum kisspeptin expression;
reproductive hormone
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(5):177-184
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effects of Ningxin Shugan decoction combined with an antagonist fixation regimen on in vitro fertilization and embryo transfer （IVF-ET） outcomes and serum kisspeptin expression in infertility patients with polycystic ovary syndrome. MethodsA total of 96 infertile patients with polycystic ovary syndrome treated in Yancheng No.1 People's Hospital and Yancheng Affiliated Hospital of Nanjing University of Chinese Medicine were enrolled in this study and randomized into control and observation groups （n=48）. The control group was treated with an antagonist fixation regimen， and the observation group was treated with Ningxin Shugan decoction on the basis of the treatment in the control group. The clinical efficacy was compared between the two groups. The total score and single scores of TCM symptoms， ovulation promotion status， and serum levels of reproductive hormones， miR-335-5p， miR-141-3p， and kisspeptin were determined before and after treatment. The IVF-ET outcome indicators and treatment safety were evaluated. Pearson test was conducted to analyze the correlations of serum levels of follicle-stimulating hormone （FSH）， kisspeptin， miR-335-5p， and miR-141-3p with IVF-ET outcomes. ResultsThe total response rate in the observation group was 90.91%， which was higher than that （70.45%） in the control group （P<0.05）. The total score and single scores of TCM symptoms and the testosterone， luteinizing hormone （LH）， and LH/FSH levels declined after treatment （P<0.05）， and they were lower in the observation group than in the control group （P<0.05）. After treatment， the serum levels of FSH， kisspeptin， miR-335-5p， and miR-141-3p rose in both groups， being higher in the observation group than in the control group （P<0.05）. The observation group showed higher ovulation number， number of MⅡ oocytes， embryo implantation rate， clinical pregnancy rate， and live birth rate than the control group （P<0.05， P<0.01）. Serum levels of FSH， kisspeptin， miR-335-5p， and miR-141-3p were positively correlated with embryo implantation rate， clinical pregnancy rate， and live birth rate （P<0.01）. ConclusionNingxin Shugan decoction combined with the antagonist fixation regimen can improve the IVF-ET outcome， promote the serum kisspeptin expression， and increase the ovulation rate and pregnancy rate in infertility patients with polycystic ovary syndrome.
