Comparison of Plaque Composition in Diabetic and Non-Diabetic Patients With Coronary Artery Disease Using Multislice CT Angiography.
10.4070/kcj.2010.40.11.581
- Author:
Yong Seop KWON
1
;
Jae Sik JANG
;
Chang Won LEE
;
Dong Kie KIM
;
Ung KIM
;
Sang Hoon SEOL
;
Doo Il KIM
;
Young Wan JO
;
Han Young JIN
;
Jeong Sook SEO
;
Tae Hyun YANG
;
Dae Kyeong KIM
;
Dong Soo KIM
Author Information
1. Department of Internal Medicine, Busan St. Mary's Hospital, Busan, Korea.
- Publication Type:Original Article
- Keywords:
Coronary artery diseases;
Diabetes
- MeSH:
Angiography;
Angioplasty;
Coronary Angiography;
Coronary Artery Disease;
Coronary Vessels;
Humans;
Multidetector Computed Tomography;
Phenobarbital;
Plaque, Atherosclerotic;
Stents
- From:Korean Circulation Journal
2010;40(11):581-586
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: Plaque composition rather than degree of luminal narrowing may be predictive of future coronary events in high risk patients. The purpose of this study was to compare degree of plaque burden and composition with multislice computed tomography (MSCT) angiography between diabetic and non-diabetic patients. SUBJECTS AND METHODS: A total of 452 consecutive MSCT angiography examinations were performed between July 2007 and June 2009. Of these, the patients who underwent invasive coronary angiography were evaluated for the presence and type of atherosclerotic plaque and severity of luminal narrowing. RESULTS: Ninety two (46 in the diabetic group and 46 in the non-diabetic group) patients underwent both MSCT angiography and invasive coronary angiography. Among them, 30 patients (65.2%) in the diabetic group and 26 patients (56.5%) in the non-diabetic group had significant coronary narrowing on MSCT angiography. Sixteen patients (34.8%) in the diabetic group and 15 patients (32.6%) in non-diabetic group underwent coronary angioplasty and stenting. Forty-two patients (93.3%) in the diabetic group and 39 patients (88.6%) in the non-diabetic group had multiple types of coronary plaque (p=0.485). MSCT angiography was similar to conventional coronary angiography in its ability to predict significant coronary artery disease in that the area under the curve was 0.88 (95% confidence interval, 0.81 to 0.95). Diabetic patients had more mixed plaque compared with non-diabetic patients. CONCLUSION: Differences in coronary plaque composition between diabetic and non-diabetic patients can be determined noninvasively by MSCT angiography. In patients with diabetes, mixed plaque types contribute to the total plaque burden to a higher degree than in non-diabetic patients.
