Analysis of the effect of fudosteine on induced sputum components in patients with stable neutrophil-dominated COPD
10.12092/j.issn.1009-2501.2024.04.001
- VernacularTitle:福多司坦对稳定期中性粒细胞为主型COPD患者诱导痰成分的影响分析
- Author:
Zhanbo LI
1
,
2
;
Kaifeng DU
;
Zhilong JIANG
;
Jiameng GAO
;
Mengjie CHEN
;
Yuan MA
;
Zhihong CHEN
Author Information
1. 复旦大学附属中山医院呼吸与危重症医学科,上海 200032
2. 复旦大学附属中山医院青浦分院呼吸与危重症医学科,上海 201700
- Keywords:
chronic obstructive pulmonary dis-ease;
induced sputum;
lung function;
fudosteine
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(4):362-369
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To observe the effect of fudostei-ne on induced sputum cell components and lung function in patients with stable neutrophil-dominat-ed COPD.METHODS:From October 2019 to Octo-ber 2022,53 patients with stable COPD were select-ed and divided into fudosteine group and placebo group.The placebo group was treated with routine treatment,and the fudosteine group was treated with fudosteine on the basis of routine treatment.The two groups were treated for 6 months.The clinical symptoms[Saint George's Respiratory Questionnaire(SGRQ),COPD Assessment Test(CAT)and Modified British Medical Research Council Dys-pnea scale(MMRC),Breathlessness,Cough,and Sputum Scale(BCSS)],lung function index,induced sputum cytology analysis and other related exami-nation results were recorded in detail before and after treatment.RESULTS:(1)Compared with the baseline,the forced expiratory volume in one sec-ond(FEV1),forced vital capacity(FVC),and the ra-tio of FEV1 to FVC(FEV1/FVC)of the two groups were improved after treatment,and the differenc-es were statistically significant(P＜0.05).However,after treatment,there was no significant difference in pulmonary function between the two groups ex-cept for the percentage of carbon monoxide diffu-sion in the predicted value(DLCO％pre)(DLCO％pre in the fudosteine group was higher than that in the placebo group).(2)After treatment,the total num-ber of induced sputum cells and neutrophil counts in the fudosteine group were lower than those in the placebo group.Compared with the number of cells in each component at baseline,the total num-ber of induced sputum cells and neutrophil count in the fudosteine group were significantly lower(P＜0.05).CONCLUSION:Fudosteine treatment in pa-tients with stable neutrophil-dominated COPD can improve lung function,reduce the total number of induced sputum cells and the total number of neu-trophils,thereby improving airway inflammation.
