A Case of Chloroquine-Induced Cardiomyopathy That Presented as Sick Sinus Syndrome.
10.4070/kcj.2010.40.11.604
- Author:
Jae Hak LEE
1
;
Woo Baek CHUNG
;
Ju Hyun KANG
;
Hyung Woo KIM
;
Jin Jin KIM
;
Ji Hyun KIM
;
Hui Jeong HWANG
;
Jea Beom LEE
;
Jong Won CHUNG
;
Hyo Lim KIM
;
Yun Seok CHOI
;
Chul Soo PARK
;
Ho Joong YOUN
;
Man Young LEE
Author Information
1. Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. myleecardio@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Hydroxychloroquine;
Cardiomyopathy, restrictive;
Sick sinus syndrome
- MeSH:
Arthritis, Rheumatoid;
Biopsy;
Cardiomyopathies;
Cardiomyopathy, Restrictive;
Connective Tissue;
Cytoplasm;
Female;
Heart Conduction System;
Hemodynamics;
Humans;
Hydroxychloroquine;
Hypertrophy;
Light;
Microscopy;
Microscopy, Electron;
Middle Aged;
Muscle Cells;
Muscles;
Patient Dropouts;
Prednisone;
Seizures;
Sick Sinus Syndrome;
Thorax
- From:Korean Circulation Journal
2010;40(11):604-608
- CountryRepublic of Korea
- Language:English
-
Abstract:
A 52-year-old woman with rheumatoid arthritis who had been treated with prednisone and hydroxychloroquine for >12 years presented with chest discomfort and a seizure. She was diagnosed with restrictive cardiomyopathy combined with sick sinus syndrome. A myocardial muscle biopsy was performed to identify the underlying cardiomyopathy, which showed marked muscle fiber hypertrophy, fiber dropout, slightly increased interstitial fibrous connective tissue, and extensive cytoplasmic vacuolization of the myocytes under light microscopy. Electron microscopy of the myocytes demonstrated dense, myeloid, and curvilinear bodies. The diagnosis of hydroxychloroquine-induced cardiomyopathy was made based on the clinical, hemodynamic, and pathologic findings. This is the first case report describing chloroquine-induced cardiomyopathy involving the heart conduction system.
