Tumor Treating Fields Plus Maintenance Temozolomide for the Treatment of Patients with Glioblastoma:a Rapid Health Technology Assessment
- VernacularTitle:肿瘤电场治疗联合替莫唑胺治疗胶质母细胞瘤的快速卫生技术评估
- Author:
Shanyan ZHOU
1
;
Yingyao CHEN
;
Zi'an XU
;
Yuliang XIANG
;
Shimeng LIU
Author Information
1. 复旦大学公共卫生学院·国家卫生健康委员会卫生技术评估重点实验室(复旦大学) 上海 200032
- Keywords:
tumor treating fields;
temozolomide;
glioblastoma;
rapid health technology assessment
- From:
Chinese Hospital Management
2024;44(10):49-54
- CountryChina
- Language:Chinese
-
Abstract:
Objective It conducted a rapid health technology assessment to evaluate the comparative safety,efficacy and economy of tumor treating fields(TTFields)combined with temozolomide treatment versus temozolomide(TMZ)alone for patients with glioblastoma(GBM).Methods It provided an extensive electronic search of databases,including PubMed,Embase,Cochrane Library,CNKI,and WanFang Data,to collect clinical evidence and health economic evaluations related to the,safety,efficacy,and economy of TTFields for Glioblastoma patients.The search covered literature from inception to July,2023,and assessed the risk of bias in the included studies.Descriptive analyses and data summaries were performed.Results A total of 19 references were included,comprising 5 randomized controlled trials,3 retrospective studies,8 systematic reviews or meta-analyses,and 3 cost-effectiveness analysis(CEA)studies.The quality of the literature evidence was heterogeneous.Recent meta-analyses mostly support the conclusion that TTFields combined with TMZ treatment provides a survival benefit compared to standard TMZ alone.However,the cost-effectiveness analysis literature from 2 countries showed different results,likely due to differences in socioeconomic levels,health systems,and heterogeneity in sources,model selection,and parameter selection.The majority of evidence supports the benefits of TTFields combined with TMZ for the treatment of GBM patients,but the results of CEAs tend to favor the view that this therapy is not cost-effective.Conclusion Current evidence indicates that TTFields combined with TMZ treatment have better safety and efficacy.However,there is still no consensus on whether it is cost-effective.
