Research progress on the physiological mechanism and regulatory network of orchitis treatment
10.3969/j.issn.1009-8291.2024.11.008
- VernacularTitle:睾丸炎治疗的生理机制与调控网络研究进展
- Author:
Yujie YANG
1
;
Zhuoxin LI
1
;
Chenrui WANG
1
;
Jiahe LIU
1
;
Qiushuang YU
1
;
Qi HOU
1
,
2
Author Information
1. Shenzhen University Health Science Center, Shenzhen 518000
2. Department of Urology, Shenzhen University General Hospital, Shenzhen 518000, China
- Publication Type:Journal Article
- Keywords:
orchitis;
autoimmune disease;
exogenous microorganism;
molecular target;
male infertility
- From:
Journal of Modern Urology
2024;29(11):969-974
- CountryChina
- Language:Chinese
-
Abstract:
Orchitis is a common male genitourinary disorder that significantly impacts patients' life quality.Current treatment strategies have certain limitations and side effects.Ongoing therapeutic strategies focus on the interactions and regulatory networks among pathways and factors involved in the progression of orchitis.The targeted pharmacological agents include inflammatory pathways (p38MAPK, NF-κB, PI3K/Akt), cytokines (TNF-α, IL-6), and the nitric oxide synthase (NOS) system.However, these studies are currently at the animal research stage, and further clinical investigations are necessary to validate their efficacy and safety before clinical use.This article reviews the preclinical animal studies on new treatment methods of orchitis from the aspects of autoimmunity and exogenous microorganism induction, including ketotifen furmarate, aspirin, L-NAME, activin A, cortisol, melatonin, methane, long non-coding RNA MEG3, Abaloparatide, recombinant type Ⅰ interferon, and so on.
