No difference in polyspermia index between older men(≥40 years) and younger men: a propensity score matching study
10.3969/j.issn.1009-8291.2024.11.004
- VernacularTitle:高龄(≥40岁)男性的多精受精指标可能与年轻男性并无显著差异：一项倾向性评分匹配研究
- Author:
Guangyao LI
1
;
Qiao ZHOU
1
;
Hui JI
1
;
Juan JI
1
;
Xiufeng LING
1
Author Information
1. Center of Reproduction Medicine, Nanjing Maternal and Child Healthcare Hospital Affiliated to Nanjing Medical University, Nanjing Maternity and Child Healthcare Hospital, Nanjing 210004, China
- Publication Type:Journal Article
- Keywords:
in vitro fertilization;
multiple pronuclei;
propensity score matching;
transferable embryos;
advanced male age
- From:
Journal of Modern Urology
2024;29(11):951-955
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To investigate the effects of advanced male age on the incidence of polyspermy fertilization. [Methods] The study involved data of 4210 in vitro fertilization (IVF) cycles treated in our center during Jan.2016 and Sep.2022, including 4053 patients younger than 40 years and 157 patients above 40 years.After propensity score matching, 152 patients in the advance group and 421 in the young group were recruited.The baseline data and the difference in polyspermy fertilization rate were compared between the two groups. [Results] After propensity score matching, there were no significant differences between the two groups in terms of female age, infertility type, infertility years, infertility factors, female body mass index (BMI), male BMI, semen volume, semen pH value, sperm concentration, sperm motility, progressive motility rate, percentage of normal sperm morphology, number of fertilized eggs and number of MⅡ eggs (P>0.05). Among the 573 fresh IVF cycles, the rate of 3 PN cycles was 35.5%, and the incidence of polyspermy fertilization was 6.5%.There were no significant differences in the number of polyspermy fertilized eggs, transferable embryos, high-quality embryos, and blastocysts between the two groups. [Conclusion] Advanced male age has no significant effect on the incidence of polyspermy fertilization.
