Predictive value of THR, MHR and NHR combined in assessing coronary artery stenosis severity and percutaneous coronary intervention
- VernacularTitle:THR、MHR和NHR对冠状动脉狭窄程度和行PCI的预测价值
- Author:
Cheng LIU
1
;
Sen LIU
1
;
Hong YANG
1
;
Menglong JIN
1
;
Ziyang LIU
1
;
Zhenyan FU
1
;
Yitong MA
1
Author Information
- Publication Type:Journal Article
- Keywords: total cholesterol to high-density lipoprotein cholesterol ratio (THR); monocyte to high-density lipoprotein cholesterol ratio (MHR); neutrophil to high-density lipoprotein cholesterol ratio(NHR); coronary artery stenosis; percutaneous coronary intervention(PCI)
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2024;45(6):948-953
- CountryChina
- Language:Chinese
- Abstract: [Objective] To investigate the value of total cholesterol to high-density lipoprotein cholesterol ratio (THR), monocyte to high-density lipoprotein cholesterol ratio (MHR), and neutrophil to high-density lipoprotein cholesterol ratio (NHR) in predicting patients’ coronary artery stenosis severity and percutaneous coronary intervention (PCI). [Methods] A total of 6 281 patients who underwent coronary angiography at our hospital between June 2021 and June 2023 were retrospectively included in this study. These patients were divided into two groups: PCI group and non-PCI group. The clinical data, laboratory findings, and interventional treatment data of all patients were collected and analyzed. Pearson correlation analysis was employed to evaluate the correlation of THR, MHR and NHR with the degree of coronary artery stenosis. Binary Logistic stepwise regression and receiver operating characteristic (ROC) curve were utilized to assess the influencing factors and predictive value of THR, MHR and NHR single and combined indexes for coronary artery disease patients undergoing PCI. [Results] The PCI group was observed to be older, with a higher proportion of males, individuals with diabetes mellitus, and those who had undergone THR, MHR, NHR, and a Gensini score than the non-PCI group. Conversely, the proportion of previous stent implantation was less than that of the non-PCI group (P<0.05). The results of Pearson correlation analysis showed a significant and positive correlation of the Gensini score with THR (r=0.351, P<0.001), MHR (r=0.192, P<0.001), and NHR (r=0.236, P<0.001) levels, indicating that these variables had a significantly positive correlation with the degree of coronary artery stenosis. The results of multifactorial Logistic regression demonstrated that age >50 years, male sex, diabetes mellitus, THR, MHR, and NHR were independent risk factors for PCI in patients with coronary artery disease. Conversely, a history of previous stent implantation was identified as a protective factor for PCI in patients with coronary artery disease. Furthermore, the results of ROC curves indicated that the combined area under the curve (AUC) was the largest for THR, MHR, and NHR (AUC=0.809, 95%CI: 0.798-0.820). [Conclusion] THR, MHR and NHR correlate with the degree of coronary stenosis and have strong clinical applications in the assessment of coronary artery disease for PCI.
