Prognostic Factors of Liposarcoma in Head and Neck
10.3971/j.issn.1000-8578.2025.24.0884
- VernacularTitle:头颈部脂肪肉瘤预后相关因素分析
- Author:
Shuo DING
1
,
2
;
Zhigang HUANG
1
,
2
;
Jugao FANG
1
,
2
;
Yang ZHANG
1
,
2
;
Lizhen HOU
1
,
2
;
Wei GUO
1
,
2
;
Gaofei YIN
1
,
2
;
Qi ZHONG
1
,
2
Author Information
1. Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
2. Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing 100730, China.
- Publication Type:SPECIALFEATURE
- Keywords:
Head and neck;
Liposarcoma;
Prognosis analysis;
Treatment
- From:
Cancer Research on Prevention and Treatment
2025;52(1):31-35
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the pathogenesis and prognostic factors of liposarcoma in the head and neck region, and simultaneously analyze the efficacy of different treatment regimens. Methods A retrospective analysis was performed on all patients with primary untreated head and neck liposarcoma who were diagnosed and underwent surgical treatment at our hospital from January 2008 to January 2024. All patients were monitored during follow-up, and their prognoses were analyzed using SPSS software. Results A total of 30 patients were included in the study. Liposarcoma accounted for up to 60% of the cases in the orbit, while the remaining liposarcomas were primarily located in various interspaces of the neck. Dedifferentiated liposarcoma was the most common type, comprising 33%, while myxoid pleomorphic liposarcoma was the rarest at 4%. The tumor pathological type (P<0.001) and Ki67 (P=0.014) significantly affected the tumor control rate. However, an analysis of disease-specific survival rates revealed no significant differences across various factors (all P>0.05). Conclusion The prognosis of head and neck liposarcoma is better compared to that of liposarcomas in other parts of the body. However, myxoid pleomorphic liposarcoma, pleomorphic fat sarcoma, and high Ki67 levels are indicators of poor prognosis. Additionally, postoperative adjuvant radiotherapy does not significantly enhance disease-specific survival rates.
