Expressions of cyclooxygenase-2 and P-glycoprotein in epithelial ovarian carcinomas.
- Author:
Soo Kyoung JUNG
1
;
Jae Seong KANG
;
In Sun KIM
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Korea University, Seoul, Korea. jskang@kumc.or.kr
- Publication Type:Original Article
- Keywords:
COX-2;
P-glycoprotein;
Ovarian carcinoma;
Chemotherapy;
Prognosis
- MeSH:
Cyclooxygenase 2*;
Drug Therapy;
Gynecology;
Humans;
Korea;
Obstetrics;
P-Glycoprotein*;
Prognosis
- From:Korean Journal of Obstetrics and Gynecology
2007;50(9):1205-1215
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The purpose of this study was to evaluate expression of cyclooxygenase-2 (COX-2) and P-glycoprotein (P-gp) in ovarian epithelial carcinomas, to find out the correlations between their expression and clinicopathological parameters, and to evaluate the response to treatment and clinical outcome according to their expression. METHODS: Immunohistochemical studies of COX-2 and P-gp were carried out in 64 cases that were treated with ovarian epithelial carcinomas at Department of Obstetrics and Gynecology, Korea University Hospital, Korea University from 1996 to 2005. RESULTS: COX-2 over-expression was detected in 20 (31.2%) cases and was significantly higher in non-responder than responder to chemotherapy (56.2% versus 22.9%, respectively; P=0.012). The patients of COX-2 overexpression showed shorter overall survival (P<0.001). Over-expression of P-gp was detected in 15 (23.4%) cases was significantly higher in non-responder than responder to chemotherapy (56.2% versus 12.5%, respectively; P<0.001). The patients of P-gp overexpression showed shorter overall survival (P= 0.042). CONCLUSION: COX-2 and P-gp overexpression could provide additional information to identify ovarian carcinoma patients with poor chance of response to chemotherapy.
