Understanding the Role of Heat Shock Protein Isoforms in Male Fertility, Aging and Apoptosis.
10.5534/wjmh.2014.32.3.123
- Author:
Kaveri PURANDHAR
1
;
Prasant Kumar JENA
;
Bhumika PRAJAPATI
;
Parth RAJPUT
;
Sriram SESHADRI
Author Information
1. Institute of Science, Nirma University, Gujarat, India. sriram.seshadri@nirmauni.ac.in
- Publication Type:Review
- Keywords:
Aging;
Heat-shock proteins;
Infertility, male;
Mitochondria;
Apoptosis
- MeSH:
Aging*;
Apoptosis*;
Cytoprotection;
Fertility*;
Heat-Shock Proteins*;
Homeostasis;
Humans;
Infertility, Male;
Male;
Mitochondria;
Physiological Processes;
Protein Isoforms*;
Spermatogenesis
- From:The World Journal of Men's Health
2014;32(3):123-132
- CountryRepublic of Korea
- Language:English
-
Abstract:
Heat shock proteins (HSPs) play a role in the homeostasis, apoptosis regulation and the maintenance of the various other physiological processes. Aging is accompanied by a decrease in the resistance to environmental stress, while mitochondria are primary targets in the process of aging, their expression decreasing with age. Mitochondrion also plays a significant role in the process of spermatogenesis. HSPs have been shown to be involved in apoptosis with some of acting as apoptotic inhibitors and are involved in cytoprotection. In this review we discuss the roles of Hsp 27, 60, 70, and 90 in aging and male infertility and have concluded that these particular HSPs can be used as a molecular markers for mitochondrially- mediated apoptosis, aging and male infertility.
