Effects of Hydro-Alcoholic Extract of Rhus coriaria (Sumac) Seeds on Reproductive Complications of Nicotinamide-Streptozotocin Induced Type-2 Diabetes in Male Mice.
10.5534/wjmh.2014.32.3.151
- Author:
Akram AHANGARPOUR
1
;
Ali Akbar OROOJAN
;
Hamid HEIDARI
;
Ghaedi EHSAN
;
Mohammad Reza RASHIDI NOOSHABADI
Author Information
1. Health Research Institute, Diabetes Research Center, Department of Physiology, Ahvaz Jundishapur University of Medical Sciences, Iran.
- Publication Type:Original Article
- Keywords:
Diabetes mellitus;
Nicotinamide;
Spermatogenesis;
Antioxidant effect;
Streptozotocin
- MeSH:
Academies and Institutes;
Animals;
Antioxidants;
Diabetes Mellitus;
Epididymis;
Follicle Stimulating Hormone;
Glyburide;
Humans;
Luteinizing Hormone;
Male;
Mice*;
Niacinamide;
Rhus*;
Sperm Count;
Spermatogenesis;
Spermatozoa;
Streptozocin;
Testis;
Testosterone
- From:The World Journal of Men's Health
2014;32(3):151-158
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The purpose of this study was to investigate the effects of the hydro-alcoholic extract of Rhus coriaria seeds on the reproductive system of nicotinamide-streptozotocin-induced type-2 diabetic mice. MATERIALS AND METHODS: In this experimental study, 56 male Naval Medical Research Institute mice were randomly divided into seven groups (n=8): control; diabetic mice; diabetic mice administered glibenclamide (0.25 mg/kg); diabetic mice who received the hydro-alcoholic extract of R. coriaria seeds (200 and 400 mg/kg groups); and normal mice who received this extract (200 and 400 mg/kg groups). Diabetes was induced by intraperitoneal administration of streptozotocin (65 mg/kg) 15 minutes after an injection of nicotinamide (120 mg/kg). Then, glibenclamide and the above mentioned extract were administered orally for 28 consecutive days. Twenty-four hours after the last treatment, serum samples, the testes, and the cauda epididymis were removed immediately for hormonal, testis morphology, and sperm parameter assessments. RESULTS: Body and testicular weight, sperm count and viability, and serum luteinizing hormone, follicle-stimulating hormone and testosterone levels were significantly lower in the diabetic mice (p<0.05). The diabetic mice treated with 400 mg/kg of the hydro-alcoholic extract of R. coriaria seeds recovered from these reductions (p<0.05). Further, glibenclamide alleviated hormonal and sperm count depletion in diabetes-induced mice (p<0.05). CONCLUSIONS: The present results indicated that the hydro-alcoholic extract of R. coriaria seeds has anti-infertility effects in diabetic males.
