Association of alcohol consumption with aortic aneurysm and dissection risk:results from the UK Biobank cohort study
10.5847/wjem.j.1920-8642.2024.096
- Author:
Liang YAOWEN
1
,
2
;
Zou GUOXIANG
;
Wang DINGCHEN
;
Zeng WEIYUE
;
Zhang JIARUI
;
Huang XIAORAN
;
Lin MIAO
;
Mai CONG
;
Song FEI'ER
;
Zhang YUELIN
;
Meng JINXIU
;
Feng HONGLIANG
;
Huang YU
;
Li XIN
Author Information
1. Department of Emergency Medicine,Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences),Southern Medical University,Guangzhou 510080,China
2. Shantou University Medical College,Shantou 515063,China
- Keywords:
Alcohol consumption;
Aortic aneurysm and dissection;
Genetic risk score;
Cohort study;
UK Biobank
- From:
World Journal of Emergency Medicine
2024;15(6):465-474
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Previous studies have reported inconsistent results with positive,negative,and J-shaped associations between alcohol consumption and the hazard of aortic aneurysm and dissection(AAD).This study aimed to examine the connections between weekly alcohol consumption and the subsequent risk of AAD. METHODS:The UK Biobank study is a population-based cohort study.Weekly alcohol consumption was assessed using self-reported questionnaires and the congenital risk of alcohol consumption was also evaluated using genetic risk score(GRS).Cox proportional hazards models were used to estimate hazard ratios(HRs)with 95%confidence intervals(CIs)for the associations between alcohol consumption and AAD.Several sensitivity analyses were performed to assess the robustness of the results. RESULTS:Among the 388,955 participants(mean age:57.1 years,47.4%male),2,895 incident AAD cases were documented during a median follow-up of 12.5 years.Compared with never-drinkers,moderate drinkers(adjusted HR:0.797,95%CI:0.646-0.984,P<0.05)and moderate-heavy drinkers(adjusted HR:0.794,95%CI:0.635-0.992,P<0.05)were significantly associated with a decreased risk of incident AAD.Interaction-based subgroup analysis revealed that the protective effect of moderate drinking was reflected mainly in participants younger than 65 years and women. CONCLUSION:Our findings support a protective effect of moderate alcohol consumption on AAD,but are limited to participants younger than 65 years and women.
