Magnesium promotes vascularization and osseointegration in diabetic states
10.1038/s41368-023-00271-y
- Author:
Liu LINFENG
1
;
Wang FEIYU
;
Song WEI
;
Zhang DANTING
;
Lin WEIMIN
;
Yin QI
;
Wang QIAN
;
Li HANWEN
;
Yuan QUAN
;
Zhang SHIWEN
Author Information
1. State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology
- From:
International Journal of Oral Science
2024;16(1):122-133
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes has long been considered a risk factor in implant therapy and impaired wound healing in soft and hard oral tissues.Magnesium has been proved to promote bone healing under normal conditions.Here,we elucidate the mechanism by which Mg2+ promotes angiogenesis and osseointegration in diabetic status.We generated a diabetic mice model and demonstrated the alveolar bone healing was compromised,with significantly decreased angiogenesis.We then developed Mg-coating implants with hydrothermal synthesis.These implants successfully improved the vascularization and osseointegration in diabetic status.Mechanically,Mg2+ promoted the degradation of Kelch-like ECH-associated protein 1(Keap1)and the nucleation of nuclear factor erythroid 2-related factor 2(Nrf2)by up-regulating the expression of sestrin 2(SESN2)in endothelial cells,thus reducing the elevated levels of oxidative stress in mitochondria and relieving endothelial cell dysfunction under hyperglycemia.Altogether,our data suggested that Mg2+ promoted angiogenesis and osseointegration in diabetic mice by regulating endothelial mitochondrial metabolism.
