Effect of Cyclophosphamide as the Treatment of Recurrent Membranoproliferative Glomerulonephritis after Renal Transplantation.
- Author:
Young Jung PARK
1
;
Hyun Su KIM
;
Heung Sik UM
;
Hwal Youn LEE
;
Sang Bong CHOI
;
Sang Hyun KIM
;
Won Do PARK
Author Information
1. Department of Internal Medicine, Sanggye Paik Hospital, Inje University School of Medicine, Seoul, Korea. wondoful1958@sanggyepaik.ac.kr
- Publication Type:Case Report
- Keywords:
Cyclophosphamide;
Recurrent type 1 membranoproliferative glomerulonephritis (MPGN);
Ascites;
Renal transplantation
- MeSH:
Ascites;
Creatinine;
Cyclophosphamide*;
Cyclosporine;
Female;
Glomerulonephritis;
Glomerulonephritis, Membranoproliferative*;
Humans;
Kidney Transplantation*;
Physical Examination;
Prednisolone;
Tomography, X-Ray Computed
- From:The Journal of the Korean Society for Transplantation
2005;19(1):58-62
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The treatment of recurrent type 1 membranproliferative glomerulonephritis (MPGN) after renal transplantation is undetermined yet. We report a case with a recurrent type 1 MPGN with ascites after renal transplantation that had a favorable outcome. A woman aged 50 was diagnosed recurrent type 1 MPGN in 2002. Afterwards she took cyclosporine, prednisolone and mycophenolate mofetil. Since August 2003, Her urine output was reduced and she suffered from abdominal distention. Serum creatinine was elevated to 2.5 mg/dL and physical examination and abdominal CT scan showed large amount of ascites. So, we substituted cyclophosphamide for mycophenolate mofetil. She was 55 kg before the substitution of cyclophosphamide but 12 months later, she weighed 44 kg and her creatinine decreased to 1.5 mg/dL. Therefore, it seems a good idea to use cyclophosphamide for the treatment of recurrent glomerulonephritis with ascites after renal transplantation.
