Immunologic characteristics and management and prospects of tar-geted biological therapy in adults with severe asthma
10.12092/j.issn.1009-2501.2024.04.008
- VernacularTitle:成人重度哮喘的免疫学特征和生物靶向治疗现状及展望
- Author:
Ao SUN
1
;
Jingluan WANG
;
Wenjuan LIU
;
Dunqiang REN
;
Xiaojing LIU
Author Information
1. 青岛大学附属医院呼吸与危重症医学科,青岛 266000,山东
- Keywords:
severe asthma;
asthma phenotypes;
biologics
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(4):415-422
- CountryChina
- Language:Chinese
-
Abstract:
Severe asthma stands as a formidable contributor to both mortality and morbidity of pa-tients suffering asthma,casting substantial social and economic shadows on communities.As our un-derstanding of asthma's pathophysiology deepens,a beacon of hope emerges in the form of biological targeted therapies,offering a promising avenue for the management of this challenging condition.These therapies,by precisely inhibiting or modulat-ing pivotal molecules in the inflammatory cascade,offer potential benefits in symptom alleviation,lung function enhancement,and risk reduction of acute exacerbations.They signify a paradigm shift in severe asthma treatment.Within the confines of this article,we embark on a systematic exploration of the immunological underpinnings that define se-vere asthma.By delving into the intricacies of the immune system's role in exacerbating this condi-tion,we aim to offer a comprehensive assessment of both the current landscape and the future pros-pects of biological therapies.Our objective is to provide a scientifically robust and valuable refer-ence that can guide the individualized treatment of patients grappling with severe asthma.
