Correlation Analysis between Preoperative Serum Estradiol Levels and Postop-erative Pregnancy Outcomes in Patients with Moderate-to-Severe Intrauterine Adhesion
- VernacularTitle:术前血清雌二醇水平与中-重度宫腔粘连术后妊娠结局的相关性分析
- Author:
Wanlin ZHANG
1
;
Daner QIU
;
Ruonan TANG
;
Xifeng XIAO
;
Xiaohong WANG
Author Information
1. 空军军医大学第二附属医院 唐都医院妇产科生殖医学中心,陕西 西安 710000
- Keywords:
Transcervical resection of adhesion;
Estrogen;
Endometrial repair
- From:
Journal of Practical Obstetrics and Gynecology
2024;40(7):586-590
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between serum estradiol(E2)levels on the day before transcervical resection of adhesion(TCRA)and pregnancy outcomes in moderate-severe intrauterine adhesion(IUA).Methods:Clinical data of patients with moderate-severe IUA diagnosed and received TCRA in the Second Affiliated Hospital of Air Force Medical University from January 2018 to December 2019 were extracted and ana-lyzed.The primary outcome indicator was the pregnancy rate during the 12-month follow-up period.Multiple re-gression analysis,smoothed curve fitting and recursive algorithm analysis were applied in this study.Results:A-mong the 288 patients who met the inclusion criteria,222 met the criteria and were finally included in the analysis.The results of multiple regression analysis showed that the E 2 level on the day before surgery was negatively cor-related with the pregnancy rate after TCRA(aOR 0.77,95% CI 0.63-0.93,P=0.0074).Recursive algorithm a-nalysis showed that when the preoperative serum E2 level was less than 380.6 pmol/L,for every increase of 36.7 pmol/L pregnancy rate decreased by approximately 20% (aOR 0.78,95% CI 0.67-0.89,P=0.0004).Conclusions:The results suggest that preoperative serum E2 levels are negatively associated with pregnancy outcomes in patients with moderate-to-severe IUA.
