Survival analysis of patients with diffuse large B-cell lymphoma after chemotherapy using Fuzheng Jiedu Formula and its mechanism of action on lymphocyte subsets
10.3969/j.issn.1006-2157.2024.11.016
- VernacularTitle:扶正解毒方辨治化疗后弥漫性大B细胞淋巴瘤患者的生存分析及其对淋巴细胞亚群的调控作用
- Author:
Xi LI
1
;
Wenyi ZHOU
;
Shiya ZHUANSUN
;
Xinbei YUAN
;
Yijie YANG
;
Hua FU
;
Wei SHEN
;
Min XU
;
Xinjin GAN
;
Jiahui LU
Author Information
1. 上海中医药大学附属龙华医院 上海 200032
- Keywords:
Fuzheng Jiedu Formula;
diffuse large B-cell lymphoma;
maintenance therapy with traditional Chinese medicine;
survival prognosis;
lymphocyte subsets
- From:
Journal of Beijing University of Traditional Chinese Medicine
2024;47(11):1603-1611
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the survival of patients with diffuse large B-cell lymphoma(DLBCL)after chemotherapy using Fuzheng Jiedu Formula and to explore the intrinsic correlation between the lymphocyte subset level and the survival of patients with DLBCL.Methods A total of 234 patients with DLBCL who had completed chemotherapy and achieved complete or partial response in the Department of Hematology,Longhua Hospital Shanghai University of Traditional Chinese Medicine and Shanghai East Hospital,Tongji University from January 1,2013,to December 31,2023,were recruited.A cohort study design was adopted,with"whether to receive continuous Fuzheng Jiedu Formula treatment for≥6 months after chemotherapy"as the exposed factor.Patients meeting this exposed factor were divided into the traditional Chinese medicine(TCM)cohort,whereas those who did not meet this exposed factor were divided into the observation cohort.The 1-and 2-year progression-free survival(PFS)rate,overall survival(OS)rate,and duration of response(DOR)of the two cohorts were compared.The survival curves of PFS and OS of the two cohorts were drawn,and subgroup survival analysis was performed to determine factors affecting disease progression.The effect of Fuzheng Jiedu Formula on lymphocyte subset count level was observed.Results The study included 126 and 108 patients in the TCM and observation cohorts,respectively.Compared with the observation cohort,the 2-year PFS rate,2-year OS rate,and DOR were increased in the TCM cohort(P<0.05).The PFS in the TCM cohort was higher than that in the observation cohort[HR=0.542,95%CI(0.345-0.853),P<0.01].The result of subgroup analysis showed that PFS in the TCM cohort was higher than that in the observation cohort in the age≥60 years,AA stage Ⅲ-Ⅳ,CD4+
