Progress of researches on mosquito salivary allergens
10.16250/j.32.1915.2024114
- VernacularTitle:蚊虫唾液过敏原研究进展
- Author:
Shangde JIANG
1
;
Xiao ZANG
1
;
Wei WANG
1
,
2
;
Shanchao HONG
3
Author Information
1. School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China
2. National Health Commission Key Laboratory on Parasitic Disease Prevention and Control, Jiangsu Provincial Key Laboratory on Parasites and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu 214064, China
3. Department of Laboratory Medicine, Jiangnan University Medical Center, Wuxi, Jiangsu 214001, China
- Publication Type:Journal Article
- Keywords:
Mosquito;
Allergen;
Saliva
- From:
Chinese Journal of Schistosomiasis Control
2024;36(6):658-663
- CountryChina
- Language:Chinese
-
Abstract:
There are multiple bioactive substances in the mosquito saliva, most of which are allergic to humans. Previous studies have demonstrated that mosquito bites may induce allergic reactions mediated by B and T lymphocytes, resulting in a reduction in the quality of life and even death among patients. To date, 11 salivary allergens and 8 non-salivary allergens have been characterized in mosquitoes. Nevertheless, there is still lack of highly sensitive, highly specific and safe tools for diagnosis of mosquito bites-induced allergy, and the difficulty in obtaining natural mosquito salivary allergens results in failure in widespread applications of immunotherapy for mosquito bites-induced allergy. This review provides an overview of the allergic symptoms of mosquito bites and underlying mechanisms, and mosquito salivary allergens that have been characterized and registered in the systematic allergen nomenclature website.
