Research progress on impact of key proteins associated with DNA damage response on radiosensitivity
10.13491/j.issn.1004-714X.2024.06.017
- VernacularTitle:DNA损伤应答关键蛋白对肿瘤放疗敏感性影响的研究进展
- Author:
Shaorong HUANG
1
;
Lianying FANG
1
;
Hao SUN
1
;
Linping ZHENG
1
;
Yingmin CHEN
2
,
3
;
Weiguo LI
1
;
Ya MA
1
Author Information
1. School of Preventive Medicine Sciences (Institute of Radiation Medicine), Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan 250117 China.
2. School of Preventive Medicine Sciences (Institute of Radiation Medicine), Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan 250117 China
3. School of Public Health, Shandong First Medical University(Shandong Academy of Medical Sciences), Jinan 250117 China.
- Publication Type:ReviewArticles
- Keywords:
Radiosensitivity;
Radiotherapy;
DNA damage response;
DNA damage repair
- From:
Chinese Journal of Radiological Health
2024;33(6):716-721
- CountryChina
- Language:Chinese
-
Abstract:
At present, the incidence and mortality of tumors are increasing, and the treatment of tumors has attracted much attention. Radiotherapy is a key method for tumor treatment; however, its effectiveness is often constrained by radioresistance. During tumor radiotherapy, DNA damage response (DDR) is a key factor in the radioresistance of tumor cells. Research has shown that the radiosensitivity of tumor cells can be effectively improved by regulating the expression of key proteins in the DDR pathway. Targeting the DDR signaling pathway has become an effective strategy to reduce tumor radioresistance. This article focuses on the mechanisms, clinical research status, limitations, and current challenges associated with the key DDR proteins DNA-PKcs, ATM, ATR, and PARP as therapeutic targets for tumor radiotherapy sensitization, in order to provide a reference for the development of radiotherapy sensitization agents.
