Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance.
- Author:
Byung Lae PARK
1
;
Yoon Jun KIM
;
Hyun Sub CHEONG
;
Lyoung Hyo KIM
;
Yoo Hyun CHOI
;
Hyo Suk LEE
;
Hyoung Doo SHIN
Author Information
1. Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul 153-803, Korea. hsleemd@snu.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
angiotensinogen;
cadherins;
cyclooxygenase 2;
carcinoma;
hepatocellular;
chemokine CCL2;
hepatitis B virus;
P-glycoprotein;
polymorphism, single nucleotide;
RANTES;
thrombospondins
- MeSH:
Promoter Regions (Genetics)/*genetics;
Polymorphism, Genetic/*genetics;
Middle Aged;
Male;
Humans;
Hepatitis B virus/*physiology;
Hepatitis B/complications/*genetics/therapy/*virology;
Haplotypes/genetics;
Female;
Chemokine CCL2/*genetics;
Carcinoma, Hepatocellular/epidemiology/etiology/genetics/virology;
Aged, 80 and over;
Aged;
Adult
- From:Experimental & Molecular Medicine
2006;38(6):694-702
- CountryRepublic of Korea
- Language:English
-
Abstract:
Hepatocellular carcinoma (HCC) is one of the most common malignant cancers closely associated with chronic infection by the hepatitis B virus (HBV) or the hepatitis C virus (HCV) throughout the world. In this study, the genetic associations of 20 known polymorphisms in eight candidate genes, including angiotensinogen (AGT), cadherin 1 (CDH1), cyclooxygenase 2 (COX2), monocyte chemotactic protein-1 (MCP1), multidrug resistance 1 (MDR1), chemokine ligand 5 (RANTES), thrombospondin 2 (THBS2), and thrombospondin 4 (THBS4), were analyzed in a large chronic hepatitis B cohort (n=1,095) recruited from the Korean population. In addition, three polymorphisms in chemokine receptor 4 (CXCR4) and vimentin (VIM) identified in this study were also genotyped. Using logistic regression analysis controlling possible confounding factors, one common (freq.=0.367) promoter polymorphism of MCP1 (MCP1-2518G>A) among analyzed polymorphisms was significantly associated with clearance of HBV infection. The frequency of homozygotes for the MCP1-2518A allele (MCP1-2518A/A) among chronic hepatitis B virus (HBV) carrier patients was significantly higher than that among spontaneously recovered (SR) subjects (17.7% vs. 10.4%)(OR=1.78, P=0.004). Our findings imply a plausible explanation for the contribution of host genetic determinants to the variable outcome of HBV infection, which might provide valuable information for future genetic study in this area.
