Role of neutrophil in fungal keratitis
10.3980/j.issn.1672-5123.2025.2.09
- VernacularTitle:中性粒细胞在真菌性角膜炎中的作用
- Author:
Junming YANG
1
,
2
,
3
;
Yanting LUO
1
,
2
,
3
;
Hong HE
1
,
2
,
3
;
Xingwu ZHONG
1
,
2
,
3
Author Information
1. Department of Ophthalmology, the First Affiliated Hospital of Hainan Medical University, Haikou 570102, Hainan Province, China
2. Hainan Eye Hospital
3. Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Haikou 570311, Hainan Province, China
- Publication Type:Journal Article
- Keywords:
neutrophils;
fungal keratitis;
immune;
macrophages;
neutrophil extracellular traps(NETs)
- From:
International Eye Science
2025;25(2):230-234
- CountryChina
- Language:Chinese
-
Abstract:
Fungal keratitis represents a significant cause of blindness, with current therapeutic approaches yielding limited success. The disease's onset and progression are primarily driven by fungal virulence factors and the host's immune response. The innate immune system is the first to respond, with neutrophils playing a pivotal role in the antifungal defense. Although neutrophils are critical for pathogen clearance, their excessive or abnormal activation can lead to tissue damage, exacerbating the disease. Thus, elucidating the mechanisms underlying neutrophil activity in fungal keratitis is crucial for refining treatment strategies. This article aims to systematically review the principal antimicrobial mechanisms employed by neutrophils, including phagocytosis, degranulation, and the formation of neutrophil extracellular traps(NETs). Furthermore, it explores the crosstalk between neutrophils and macrophages, alongside their collective impact and underlying mechanisms in the context of fungal keratitis. Exploration of the mechanisms of fungal keratitis facilitates precise intervention and enhances the efficacy of treatment.
