Invasion and Metastasis in Colorectal Cancer Mediated by Traditional Chinese Medicine via Cell Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20241523
- VernacularTitle:中医药基于信号通路调控结直肠癌侵袭转移研究进展
- Author:
Min GUO
1
;
Wenyan YU
1
;
Naicheng ZHU
1
;
Yuwei YAN
1
;
Chen ZHONG
1
;
Xiudan CHEN
2
;
Nanxin LI
2
;
Guojuan WANG
2
Author Information
1. Research Center for Differentiation and Development of Basic Theory of Traditional Chinese Medicine，Jiangxi University of Chinese Medicine，Nanchang 330004， China
2. Affiliated Hospital of Jiangxi University of Chinese Medicine，Nanchang 330006， China
- Publication Type:Journal Article
- Keywords:
colorectal cancer;
traditional Chinese medicine;
invasion and metastasis;
signaling pathway;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(4):323-330
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer is a common and malignant tumor in the digestive tract. Invasion and metastasis of cancer cells are key factors leading to the high mortality rate and postoperative recurrence of colorectal cancer. Chemotherapy is the main treatment method for preventing recurrence of this disease. However， there are many toxic side effects in clinical application， which seriously hinder the treatment process. Therefore， it is imperative to search for efficient and low-toxicity drugs. Traditional Chinese medicine （TCM） has a long history of treating colorectal cancer and offers advantages such as safety， effectiveness， multiple targets， multiple pathways and minimal toxic side effects， which have made it increasingly popular worldwide. According to TCM， the pathogenesis of colorectal cancer is rooted in both deficiency and excess. TCM formulas mainly focus on tonifying the body to address the invasion and metastasis of colorectal cancer， such as Jianpi compound， Jianpi Xiaoai decoction， and Bushen Jiedu Sanjie decoction. TCM monomers， such as emodin， berberine， and tanshinone， mainly focus on clearing heat and removing toxin， circulating blood and transforming stasis， and resolving swelling and dispersing nodules. Signaling pathways play a crucial role for analyzing invasion and metastasis， and research has shown that pathways such as Wnt/β-catenin， phosphatidylinositol-3 kinase/protein kinase （PI3K/Akt）， Janus kinase 2/signal transduction and transcription activating factor 3 （JAK2/STAT3）， nuclear factors-κB （NF-κB）， vascular endothelial growth factor （VEGF） play important roles in the invasion and metastasis of colorectal cancer. The invasion and metastasis of colorectal cancer can be inhibited via regulating the key proteins and related factors in these pathways. In this review， we searched various literature databases， such as PubMed， China National Knowledge Infrastructure （CNKI）， and VIP， using keywords such as "colorectal cancer"， "signaling pathway"， "invasion and metastasis"， and "traditional Chinese medicine"， to summarize and analyze the relevant pathways of TCM compounds and monomers against invasion and metastasis of colorectal cancer published in the past five years. The review aims to provide new insights and references for in-depth research on the therapy for invasion and metastasis of colorectal cancer and new drug development.
