Treatment of Parkinson's Disease with Traditional Chinese Medicine by Regulating BDNF/TrkB Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20250268
- VernacularTitle:中医药调控BDNF/TrkB通路治疗帕金森病的研究进展
- Author:
Lulu JIA
1
;
Ying LI
1
;
Jiale YIN
1
;
Nan JIA
1
;
Xiaoxi LIU
1
;
Li LING
1
Author Information
1. Affiliated Hospital of Hebei University，Baoding 071000，China
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
α-synuclein;
dopaminergic neurons;
brain-derived neurotrophic factor（BDNF）/tyrosine kinase receptor B（TrkB） signaling pathway;
traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(4):315-322
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease（PD） is the second most common neurodegenerative disease in the world， which seriously affects the lives of patients. With the acceleration of aging process， the number of patients continues to rise. Its main pathological features are aggregation of α-synuclein and degenerative death of dopaminergic neurons in the substantia nigra. However， the pathogenesis of PD is still unclear. According to reports， the brain-derived neurotrophic factor（BDNF）/tyrosine kinase receptor B（TrkB） signaling pathway is highly expressed and activated in dopaminergic neurons in the substantia nigra， which is closely related to neurophysiological processes such as neurogenesis， synaptic plasticity， neuroinflammation， and oxidative stress. It plays an important role in the occurrence and development of PD. At present， the treatment methods of Western medicine for PD are mainly based on drugs such as levodopa and dopamine agonists to alleviate motor symptoms， but with the increase of dose， the adverse reactions are significantly enhanced. Traditional Chinese medicine（TCM） has attracted people to explore its therapeutic effects on PD due to its characteristics of homology of medicine and food， economy， minor adverse reactions and multi-target action. Therefore， this paper systematically reviews the role of BNDF/TrkB pathway in the pathogenesis of PD and the mechanism of TCM formulas， extracts and monomers in the treatment of PD by regulating the BNDF/TrkB pathway according to retrieving the latest research reports at home and abroad， so as to provide a reference for the clinical application of related TCM and the development of new drugs for PD.
