Traditional Chinese Medicine in Prevention and Treatment of Depression Based on Ferroptosis Theory： A Review
10.13422/j.cnki.syfjx.20241242
- VernacularTitle:基于铁死亡理论探讨中医药防治抑郁症的研究进展
- Author:
Chenjie HUANG
1
;
Mingli FAN
1
;
Xueli SHI
2
Author Information
1. Graduate School， Guangxi University of Chinese Medicine， Nanning 530200， China
2. Zhuang Medicine College， Guangxi University of Chinese Medicine， Nanning 530001， China
- Publication Type:Journal Article
- Keywords:
ferroptosis;
depression;
traditional Chinese medicine;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(4):307-314
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a novel form of programmed cell death that plays a critical role in the body's disease resistance processes. Research has shown that ferroptosis plays a significant role in the pathogenesis of depression. Traditional Chinese medicine （TCM） has unique advantages in the prevention and treatment of depression， and the effective application of ferroptosis theory to guide TCM in the prevention and treatment of depression has become a current research hotspot. This article provides a summary and review of the regulatory mechanisms of ferroptosis， its relationship with depression， and the current research status of TCM in the prevention and treatment of depression based on ferroptosis. It has been found that the occurrence of ferroptosis is related to processes such as iron metabolism disorders， uncontrolled lipid peroxidation， and abnormal amino acid metabolism. Ferroptosis plays an important regulatory role in the onset， progression， and treatment of depression， offering new ideas for therapeutic approaches to the condition. Additionally， research on TCM interventions that regulate ferroptosis to exert antidepressant effects has identified several effective components， such as saikosaponin B2， luteolin， quercetin， gallic acid， catalpol， turmerone， oxypaeoniflorin， and traditional compound formulas such as Dihuang Yinzi and Xiaoyaosan， as well as acupuncture and moxibustion. These interventions have been shown to exert antidepressant effects by regulating ferroptosis， providing scientific evidence and references for further research into ferroptosis theory and its application in guiding the prevention and treatment of depression through TCM.
