Traditional Chinese Medicine Regulates JAK/STAT Signaling Pathway to Treat Colorectal Cancer： A Review
10.13422/j.cnki.syfjx.20241429
- VernacularTitle:中药调控JAK/STAT信号通路抗结直肠癌的研究进展
- Author:
Mingxing WANG
1
;
Wanhui DONG
1
;
Baorui ZHANG
1
;
Tong LAI
1
;
Aixin LIU
1
;
Qingming SUN
1
Author Information
1. Lu'an Hospital of Traditional Chinese Medicine Affiliated to Anhui University of Chinese Medicine， Lu'an 237005， China
- Publication Type:Journal Article
- Keywords:
Janus kinase/signal transducer and activator of transcription （JAK/STAT）;
colorectal cancer;
compound prescription of traditional Chinese medicine;
active components of traditional Chinese medicine;
cell proliferation;
cell apoptosis;
sensitivity to chemotherapy
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(4):278-287
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer （CRC） ranks as the second leading cause of cancer death worldwide. Although preventive colonoscopy screening has improved the survival rate of CRC patients in the past few years， there are still many patients diagnosed after symptoms appear. The surgery for CRC carries high risks and high recurrence， and ideal therapies remain to be developed. The Janus kinase/signal transducer and activator of transcription （JAK/STAT） signaling pathway has become a focus of research due to its central role in cellular activities. As a classic oncogenic pathway， the JAK/STAT signaling pathway offers new possibilities for diagnosing and treating various malignancies， and it paves a new way for developing therapies for CRC. This pathway not only participates in basic cellular processes， such as proliferation， differentiation， and apoptosis but also plays a crucial role in immune responses and inflammation. Abnormal activation of the JAK/STAT signaling pathway is closely related to the occurrence and development of CRC. Studies have shown that the active components and compound prescriptions of traditional Chinese medicine （TCM） can inhibit the proliferation， invasion， migration， and angiogenesis while promoting the apoptosis and autophagy of CRC cells by interfering with the JAK/STAT signaling pathway. Furthermore， this pathway may also play a role in regulating the sensitivity of tumor cells to chemotherapy and radiotherapy， thus influencing the effectiveness of tumor treatment and impeding the progression of CRC. In recent years， research results have been updated rapidly， and previous literature summaries have failed to incorporate the latest findings， creating obstacles to accessing current literature. Therefore， this article supplements and summarizes information from the definition of the JAK/STAT pathway， association of this pathway with CRC， and TCM intervention of CRC. This review aims to provide references for future development of molecular biology regarding CRC and the research and development of new drugs.
