Application of Zebrafish in Quality Evaluation of Traditional Chinese Medicine
10.13422/j.cnki.syfjx.20241012
- VernacularTitle:斑马鱼在中药品质评价中的应用进展
- Author:
Jiaqi LI
1
;
Xiaolu CHEN
1
;
Jiarui WU
1
;
Xiaoyu TAO
1
;
Qiqi FAN
1
;
Shengyun DAI
2
;
Chongjun ZHAO
1
Author Information
1. Beijing Key Laboratory for Quality Evaluation of Chinese Materia Medical/Traditional Chinese Medicine（TCM） Processing Technology Inheritance Base of National Administration of TCM， School of Chinese Materia Medica， Beijing University of Chinese Medicine， Beijing 102488， China
2. National Institutes for Food and Drug Control， Beijing 102629， China
- Publication Type:Journal Article
- Keywords:
zebrafish;
traditional Chinese medicine;
quality evaluation;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(4):58-70
- CountryChina
- Language:Chinese
-
Abstract:
As a new type of model organism， zebrafish is gradually gaining prominence in the field of scientific research. The unique biological characteristics and advantages of zebrafish make them play an increasingly important role in the quality evaluation of traditional Chinese medicine. Compared with other common experimental animals， zebrafish have a fast reproductive and growth speed and high embryo transparency， making them an ideal model for evaluating the quality of traditional Chinese medicine. This provides a new perspective and method for research on traditional Chinese medicine. With the growing global interest in traditional Chinese medicine， it has become crucial to find scientific and accurate methods to evaluate the quality and effectiveness of traditional Chinese medicine. The introduction of the zebrafish model has brought new breakthroughs in the quality evaluation of traditional Chinese medicine. To further promote the application of zebrafish in evaluating the quality of traditional Chinese medicine， this article systematically searched and sorted out the previous studies related to the application of zebrafish for this purpose since 2023. The commonly used disease models and indicators of zebrafish in evaluating the effectiveness of traditional Chinese medicine， as well as the mechanism of zebrafish in exploring the active ingredients of traditional Chinese medicine， were primarily reviewed. The application of zebrafish in evaluating the safety of traditional Chinese medicine and the typical examples in ensuring the quality of traditional Chinese medicine were demonstrated. The limitations encountered by zebrafish models in evaluating the quality of traditional Chinese medicine were highlighted. The resolution of these problems will help further improve the accuracy and reliability of zebrafish in evaluating the quality of traditional Chinese medicine. The article discussed the evaluation of effectiveness， safety， and quality control of zebrafish applied in traditional Chinese medicine， so as to provide a reference for establishing standards for traditional Chinese medicine and promoting its modernization in the future.
