Programmed Cell Death in Endometriosis and Traditional Chinese Medicine Intervention： A Review
10.13422/j.cnki.syfjx.20242145
- VernacularTitle:子宫内膜异位症程序性细胞死亡和中医药干预作用研究进展
- Author:
Zuoliang ZHANG
1
;
Wanrun WANG
1
;
Wen LI
2
;
Xue HAN
2
;
Xiaohong CHEN
2
;
Nan SU
2
;
Huiling LIU
2
;
Quansheng WU
1
Author Information
1. Clinical College of Chinese Medicine， Gansu University of Chinese Medicine， Lanzhou 730000，China
2. Gansu Provincial People's Hospital， Lanzhou 730000， China
- Publication Type:Journal Article
- Keywords:
endometriosis;
programmed cell death;
traditional Chinese medicine;
apoptosis;
pyroptosis;
autophagy;
ferroptosis;
cuproptosis
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(4):48-57
- CountryChina
- Language:Chinese
-
Abstract:
Endometriosis （EMT） is a common disease with frequent occurrence and difficult to be cured in modern clinical practice of obstetrics and gynaecology. It is characterized by progressively worsening dysmenorrhoea， pelvic mass， and infertility. The incidence of EMT is growing and increasingly younger patients are diagnosed with this disease， which poses a serious threat to the reproductive and psychological health of women of childbearing age and adolescent females. However， the pathogenesis of EMT is still not completely clear， and the disease has a long course. Therefore， developing new therapies is an urgent clinical problem to be solved. Great progress has been achieved in the treatment of EMT with traditional Chinese medicine （TCM）， while the underlying mechanism remains in exploration. Programmed cell death （PCD） is a cell death mode mediated by a variety of bio-molecules with specific signaling cascades. The known PCD processes include apoptosis， pyroptosis， autophagy， ferroptosis， and cuproptosis， which all play a pivotal role in the development of EMT. Researchers have made achievements in the treatment of EMT with TCM， which regulates PCD via multiple pathways， routes， targets， and mechanisms. However， the progress in the regulation of PCD in the treatment of EMT with TCM remains to be reviewed. This paper reviews the research progress in the treatment of EMT with TCM from five PCD processes （apoptosis， pyroptosis， autophagy， ferroptosis， and cuproptosis）， with the aim of providing a theoretical basis for the clinical prevention and treatment of EMT.
