Comparative study of pharmacodynamic experiments on compound Heishen drop pills and compound Heishen pills
10.12206/j.issn.2097-2024.202404009
- VernacularTitle:复方黑参滴丸与复方黑参丸药效学实验比较研究
- Author:
Jing HE
1
;
Ye AN
1
;
Chaoshen ZHANG
1
Author Information
1. Department of Pharmacy, General Hospital of Northern Theater Command of the PLA, Shenyang 110840, China.
- Publication Type:ColumnfromGeneralHospitalofNorthernTheaterCommand
- Keywords:
compound Heishen drop pills;
compound Heishen pills;
anti-inflammatory function;
eliminating phlegm
- From:
Journal of Pharmaceutical Practice and Service
2025;43(1):17-21
- CountryChina
- Language:Chinese
-
Abstract:
Objection To study and compare the pharmacodynamics in the treatment of chronic pharyngitis between Compound Heishen pills and Compound Heishen Drop pills. Methods Sixty healthy Wistar rats were randomly divided into blank group, positive control group and treatment group. The foot swelling thickness of each rat was measured at 1.0, 2.0, 3.0, 4.0, 5.0 and 6.0 h after inflammation, and the foot swelling rate of each rat was calculated. Through the experimental model of rat toe swelling, the inhibition of foot swelling induced by carrageenan was observed by two dosage forms: drop pill and pill. Sixty healthy Kunming mice were randomly divided into the blank group, positive control group and treatment group. After 4 days of continuous intragastric administration, the mice were intraperitoneally injected with 0.5% phenol red solution. After 30min, the mice were sacrificed, their trachea was dissected and washed with 0.5%NaHCO3 solution. The washing solution was put into ultraviolet spectrophotometer, and the absorbance was measured at 546 nm to calculate the corresponding concentration of phenolic red. Through the expectorant experiment of phenol red in mice, the effects of dropping pill and pill on the secretion of phenol red in experimental mice respiratory tract were compared. Results The experimental results of toes swelling in rats showed that compared with the blank experimental group, the five groups all had significant inhibition effect on acute foot swelling induced by carrageenan in rats. Compared with traditional form group, improved form had significant difference. The results of phenol red sputum removing experiment in mice showed that compared with the blank group，the amount of phenol red secretion in mice was increased in 5 test groups. There was no significant difference between improved form and traditional form in the amount of phenol red secretion in mice. Conclusion Both preparations had the function of anti-inflammatory and eliminating phlegm. There were no remarkable differences between the two preparations in pharmacologic actions.
