Current status of diagnosis and treatment of steroid resistant acute rejection after liver transplantation
10.12464/j.issn.1674-7445.2024202
- VernacularTitle:肝移植术后耐激素性急性排斥反应的诊疗现状
- Author:
Huabin PENG
1
;
Liying SUN
2
,
3
Author Information
1. Department of Intensive Liver Disease, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
2. Department of Intensive Liver Disease, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
3. .
- Publication Type:ReviewArticle
- Keywords:
Liver transplantation;
Acute rejection;
Steroid resistance;
T cell-mediated rejection;
Antibody-mediated rejection;
Donor specific antibody;
Tacrolimus;
Mycophenolate mofetil
- From:
Organ Transplantation
2025;16(1):156-162
- CountryChina
- Language:Chinese
-
Abstract:
After the occurrence of acute rejection following solid organ transplantation, high-dose glucocorticoid (steroid) pulse therapy is commonly used. However, high-dose steroid pulse therapy is ineffective for some patients, leading to steroid resistant acute rejection, which may easily result in graft loss and severely affect patient prognosis. It is currently believed that both cell-mediated rejection and antibody-mediated rejection are involved in the occurrence and development of steroid resistant acute rejection. The diagnosis and treatment of steroid resistant acute rejection after kidney transplantation have become relatively mature, while the focus on steroid resistant acute rejection after liver transplantation has been relatively low in the past in China, and a unified standardized treatment plan has not yet been formed. Therefore, this article reviews the pathogenesis, diagnosis, and treatment of steroid resistant acute rejection after liver transplantation, in order to provide a reference for the diagnosis and treatment of steroid resistant acute rejection after liver transplantation.
