Pathogenic characteristics and drug sensitivity analysis of hospital-acquired infections in lung transplant recipients: a single-center 5-year retrospective study
10.12464/j.issn.1674-7445.2024235
- VernacularTitle:肺移植受者术后医院感染病原学特点及药敏分析：一项单中心5年回顾性调查研究
- Author:
Sangsang QIU
1
;
Qinfen XU
1
;
Bo WU
2
;
Xiaojun CAI
2
;
Qinhong HUANG
1
;
Dapeng WANG
2
;
Chunxiao HU
2
;
Jingyu CHEN
2
Author Information
1. Wuxi Medical Center, Nanjing Medical University, Wuxi People's Hospital, Department of Infection Management, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi 214023, China.
2. .
- Publication Type:OriginalArticle
- Keywords:
Lung transplantation;
Hospital-acquired infection;
Multidrug-resistant organism;
Acinetobacter baumannii;
Pseudomonas aeruginosa;
Klebsiella pneumoniae;
Stenotrophomonas maltophilia;
Antimicrobial agent
- From:
Organ Transplantation
2025;16(1):114-121
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the characteristics of postoperative hospital-acquired infections and drug sensitivity in lung transplant recipients over the past 5 years in a single center. Methods A total of 724 lung transplant recipients at Wuxi People's Hospital from January 2019 to December 2023 were selected. Based on the principles of hospital-acquired infection diagnosis, a retrospective analysis was conducted on the hospital infection situation and infection sites of lung transplant recipients, and an analysis of the distribution of hospital-acquired infection pathogens and their antimicrobial susceptibility test status was performed. Results Among the 724 lung transplant recipients, 275 cases of hospital-acquired infection occurred, with an infection rate of 38.0%. The case-time infection rate decreased from 54.2% in 2019 to 22.8% in 2023, showing a downward trend year by year (Z=30.98, P<0.001). The main infection site was the lower respiratory tract, accounting for 73.6%. The pathogens were mainly Gram-negative bacteria, with the top four being Acinetobacter baumannii (37.1%), Pseudomonas aeruginosa (17.3%), Klebsiella pneumoniae (13.7%), and Stenotrophomonas maltophilia (13.4%), with imipenem resistance rates of 89%, 53%, 58% and 100%, respectively. Gram-positive bacteria were mainly Staphylococcus aureus (3.6%), with a methicillin resistance rate of 67%. Conclusions Over the past 5 years, the hospital-acquired infections in lung transplant recipients have shown a downward trend, mainly involving lower respiratory tract infections, with the main pathogens being Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae, all of which have high resistance rates to imipenem.
