Effect of Acupuncture Combined with Bloodletting and Cupping on the Expression of Coagulation-Complement-Mast Cell Activation Axis-Related Factors in Patients with Chronic Spontaneous Urticaria：Randomize-controlled Study
10.13288/j.11-2166/r.2025.02.009
- VernacularTitle:针刺结合刺血拔罐对慢性自发性荨麻疹患者凝血-补体-肥大细胞活化轴相关因子表达的影响
- Author:
Yuzhu DU
1
;
Yuqiang XUE
1
;
Xiang LIU
2
;
Yu SHI
3
;
Hongkun LI
4
;
Wenshan LIU
5
;
Zan TIAN
2
;
Yutong HU
2
;
Yanjun WANG
2
Author Information
1. Hebei University of Chinese Medicine，Shijiazhuang，050200
2. The First Affiliated Hospital of Hebei University of Chinese Medicine
3. Affiliated Hospital of Hebei University
4. The Second Hospital of Hebei Medical University
5. The Third Hospital of Hebei Medical University
- Publication Type:Journal Article
- Keywords:
chronic spontaneous urticaria;
acupuncture;
bloodletting;
cupping;
mast cell;
inflammatory factor;
coagulation;
complement
- From:
Journal of Traditional Chinese Medicine
2025;66(2):150-156
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the clinical efficacy of acupuncture combined with bloodletting and cupping in the treatment of chronic spontaneous urticaria（CSU） and to explore its potential mechanisms of action. MethodsSeventy CSU patients were randomly divided into loratadine group and acupuncture + bloodletting group， with 35 patients in each group. The loratadine group received oral loratadine tablets， 10 mg once daily in the evening. The acupuncture + bloodletting group received acupuncture at Zhongwan （CV 12）， Guanyuan （CV 4）， Tianshu （ST 25）， Zusanli （ST 36）， Sanyinjiao （SP 6）， Xuehai （SP 10）， Quchi （LI 11）， Hegu （LI 4）， Taichong （LR 3）， Baihui （GV 20）， and Shenting （GV 24）， once daily，along with bloodletting and cupping at Dazhui （GV 14） and Geshu （BL 17）， every other day. Both groups were treated for 4 weeks. The 7-day urticaria activity score（UAS7） was assessed before and after the treatment， and levels of serum immunoglobulin E （IgE）， interleukin-4 （IL-4）， interleukin-5 （IL-5）， eosinophil cationic protein （ECP）， plasma tissue factor （TF）， activated factor Ⅶ （FⅦa）， prothrombin fragment 1+2 （F1+2）， D-dimer （D-D） and complement component 5a （C5a） were detected. ResultsA total of 65 patients were included in the final analysis， 32 in the loratadine group and 33 in the acupuncture + bloodletting group. Before treatment， there was no significant difference in UAS7 score， serum IgE， IL-4， IL-5， ECP levels， or plasma TF， FⅦa， F1+2， D-D， C5a levels between groups （P＞ 0.05）. After treatment， both groups showed significant reductions in UAS7 score， serum IgE， IL-4， IL-5， and plasma TF， FⅦa， F1+2， D-D， and C5a levels compared to those before treatment （P＜0.01）. However， after treatment， there was no significant difference in UAS7 score and serum ECP， IgE， IL-4， IL-5 levels between groups （P＞0.05）. The acupuncture + bloodletting group showed lower plasma TF， FⅦa， F1+2， D-D and C5a levels compared to the loratadine group （P＜0.05 or P＜0.01）. ConclusionAcupuncture combined with bloodletting and cupping can effectively improve the skin symptoms of CSU patients and reduce the levels of inflammatory factors. The potential mechanism of action may involve the regulation of the coagulation-complement-mast cell activation axis， thereby inhibiting mast cell degranulation.
