The Effect of Bone Immune Microenvironment and Bone Mesenchymal Stem Cells on the Heterotopic Ossification of Ankylosing Spondylitis Based on the Theory of "Bone Sweat Pore-Kidney Visceral Manifestation"
10.13288/j.11-2166/r.2025.02.005
- VernacularTitle:从“骨玄府-肾藏象”探析骨免疫微环境与间充质干细胞对强直性脊柱炎异位骨化的影响
- Author:
Yuening CHEN
1
;
Hongxiao LIU
1
Author Information
1. Guang'anmen Hospital， China Academy of Chinese Medical Sciences，Beijing，100053
- Publication Type:Journal Article
- Keywords:
ankylosing spondylitis;
bone sweat pore;
kidney visceral manifestation;
bone immune microenvironment;
bone mesenchymal stem cells;
heterotopic ossification
- From:
Journal of Traditional Chinese Medicine
2025;66(2):128-132
- CountryChina
- Language:Chinese
-
Abstract:
Heterotopic ossification is an important pathological link leading to disability in ankylosing spondylitis （AS）. Imbalance of bone immune microenvironment is the initiating factor for heterotopic ossification in AS， while abnormal osteogenic potential of bone marrow mesenchymal stem cells （BMSCs） is the core link. From the perspective of "bone sweat pore-kidney visceral manifestation" in traditional Chinese medicine， it is believed that dysfunction of "kidney visceral manifestation" is the basis for the induction of heterotopic ossification by bone immune microenvironment and BMSCs， and "bone sweat pore" is their important setting. Accordingly， it is proposed that the kidney and sweat pore should be nourished and regulated to reshape the bone immune microenvironment and BMSCs function， and that obstruction should be removed and the marrow should be unblocked to eliminate the pathological factors that lead to AS heterotopic ossification. This provides a new perspective and basis for the treatment of AS with traditional Chinese medicine.
