Research progress of chitinase 3-like protein 1 in the pathogenesis of pulmonary fibrosis
10.20001/j.issn.2095-2619.20241020
- VernacularTitle:壳多糖酶3样蛋白1在肺纤维化发病机制中的研究进展
- Author:
Yifan QUAN
1
;
Cunxiang BO
Author Information
1. Shandong Institute of Occupational Health and Occupational Disease Prevention, Jinan, Shandong 250062, China
- Publication Type:Review
- Keywords:
Chitinase 3-like protein 1;
Pulmonary fibrosis;
Lung disease;
Inflammatory factors;
Cytokines;
Pathogenesis;
Research progress
- From:
China Occupational Medicine
2024;51(5):592-597
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary fibrosis is an end-stage alteration of lung diseases characterized by fibroblast proliferation and accumulation of extracellular matrix with inflammatory damage and tissue structure destruction. The pathogenesis of pulmonary fibrosis has not been fully defined. Chitinase 3-like protein 1 (CHI3L1) plays an important role in various fibrotic diseases characterized by inflammation and tissue remodeling. During the development of pulmonary fibrosis, CHI3L1 promotes the release of inflammatory factors by binding to receptors such as chemoattractant receptor homologous molecule expressed on T-helper type-2 cells, interleukin (IL) -13 receptor subunit alpha-2, and galectin-3. CHI3L1 facilitates pulmonary fibrosis by modulating the levels of transforming growth factor-beta 1 and IL-18. Additionally, CHI3L1 contributes to pulmonary fibrosis by participating in immune responses mediated by multiple cytokines and inflammatory factors, and directly facilitate pulmonary fibrosis by mediating the activity of pulmonary fibroblasts and alveolar macrophages. Moreover, CHI3L1 can serve as a biomarker for the diagnosis and treatment for lung diseases. However, specific therapeutic targets for CHI3L1 in pulmonary fibrosis remain unavailable. Future research should aim to identify unknown specific receptors or ligands for CHI3L1 and investigate its functions in various physiological and pathological responses.
