Research progress on the association between environmental pollutants and incidence of diabetes
10.20001/j.issn.2095-2619.20241019
- VernacularTitle:环境污染物与糖尿病发病关联研究进展
- Author:
Jingxue ZHANG
1
;
Yunpeng CUI
;
Mingyi XU
;
Xixi LI
;
Linlin SAI
Author Information
1. Shandong First Medical University (Shandong Academy of Medical Sciences), Shandong Academy of Occupational Health and Occupational Medicine, Jinan, Shandong 250062, China
- Publication Type:Review
- Keywords:
Diabetes;
Environmental pollutants;
Organochlorine pesticides;
Polychlorinated biphenyls;
Phthalates;
Arsenic;
Incidence association;
Research progress
- From:
China Occupational Medicine
2024;51(5):586-591
- CountryChina
- Language:Chinese
-
Abstract:
The research focus of diabetes, a common chronic metabolic disease, has shifted from individual factors to environmental factors at the population level. Epidemiological studies suggest an association between exposure to environmental pollutants and the risk of diabetes. Major environmental pollutants include organochlorine pesticides, polychlorinated biphenyls, phthalates and their metabolites, and arsenics, which primarily enter the human body through the skin, respiratory tract, and digestive system. Long-term exposure to these pollutants can affect the pathology of diabetes through various mechanisms, such as promoting insulin resistance, causing insulin secretion deficiencies, inducing oxidative stress-induced glucose metabolism disorders, and affecting DNA methylation. However, the potential damaging mechanism of the impact of environmental pollutants on diabetes remain unclear. Limitations such as insufficient sample sizes, uncertainties regarding exposure time and dosage, and differences between single and co-exposures. In the future, it is necessary to focus on exploring and analyzing the mechanisms of environmental pollutant exposure on diabetes to develop effective prevention strategies, control and reduce the incidence and development of diabetes, and provide new insights into its diagnosis and treatment.
