Advances in rapid detection methods of biotoxins in blood
10.20001/j.issn.2095-2619.20241017
- VernacularTitle:血液中生物毒素快速检测方法研究进展
- Author:
Wenjie ZHANG
1
;
Yiru QIN
;
Zuofei XIE
;
Anping MA
;
Jingjing QIU
;
Zuokan LIN
;
Jiaheng HE
;
Zhanhong YANG
;
Weifeng RONG
;
Banghua WU
Author Information
1. School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong 510080, China
- Publication Type:Review
- Keywords:
Biotoxins;
Rapid detection;
Detection methods;
Blood;
Biosensors;
Immunoassays;
Research progress
- From:
China Occupational Medicine
2024;51(5):575-580
- CountryChina
- Language:Chinese
-
Abstract:
Biotoxins, which include bacterial, fungal, marine, plant, and animal toxins, are widespread in living and occupational environments, posing potential threats to human health. Rapid detection of biotoxins in blood is crucial for preventing health hazards and enabling timely disease diagnosis and treatment. Biosensors and immunoassay technologies have critical advantages in the rapid detection of biotoxins in blood. Common biosensors, such as surface plasmon resonance biosensors and fluorescent biosensors, enhance sensitivity and reduce detection limits through signal amplification. Common immunoassay methods, such as colloidal gold immunochromatography, fluorescence immunochromatography, and chemiluminescence immunoassay, improve detection efficacy and sensitivity through specific antibody-antigen binding and nanotechnology. However, current rapid detection technologies of bitoxins in blood face challenges such as matrix interference and insufficient specificity, and they fall short in high-throughput detection of multiple toxins simultaneously. Future developments should focus on improving sample pretreatment, innovating signal amplification methods, enhancing specificity on recognition of elements, and designing portable detection devices and high-throughput platforms for simultaneous toxin analysis. These advancements aim to improve the sensitivity and reliability of detection methods, providing more accurate and convenient solutions for biotoxin detection in blood.
