Research and prospect on carcinogenic heavy metals and metalloids-induced occupational tumors
10.20001/j.issn.2095-2619.20241001
- VernacularTitle:致癌性重金属与类金属所致职业性肿瘤研究与展望
- Author:
Zhiqiang JI
1
;
Guiping HU
;
Guang JIA
Author Information
1. School of Public Health, Peking University, Beijing 100191, China
- Publication Type:Journal Article
- Keywords:
Carcinogenesis;
Heavy metals;
Metalloids;
Occupational tumor;
Tertiary prevention;
Mechanisms;
Biomarkers;
Occupational health surveillance
- From:
China Occupational Medicine
2024;51(5):481-487
- CountryChina
- Language:Chinese
-
Abstract:
Malignant tumors are a prominent societal and public health challenges. Occupational tumors, as a subset of malignant tumors, have drawn considerable attention, particularly those caused by carcinogenic heavy metals and metalloids. The International Labor Organization has classified malignant tumors caused by hexavalent chromium compounds, arsenic and its inorganic compounds, cadmium and its compounds, and nickel compounds as occupational diseases, while China only classified lung cancer caused by hexavalent chromium compounds and lung and skin cancers caused by arsenic and its inorganic compounds as occupational diseases. In term of prevention and treatment of occupational tumors caused by carcinogenic heavy metals and metalloids, the principles of tertiary prevention should be followed, and the focus should be paid to combation of carcinogen exposure assessments and tertiary prevention strategies to set up a comprehensive system of prevention and treatment. Multiple effort on its source control, etiology diagnosis, biomarker research, and high-risk population screening can effectively reduce the risk of occupational tumors and improve patients′ quality of life. Advancing research on the mechanisms of occupational tumors caused by carcinogenic heavy metals and metalloids and improving study on the occupational health surveillance are crucial for early screening, diagnosis, and treatment of occupational tumors. Future study on occupational tumors caused by carcinogenic heavy metals and metalloids should combine the etiology, pathogenesis, and tertiary prevention strategies with active application of artificial intelligence. Therefore, developing a preventive model that encompasses the entire occupational population and life cycle will offer support for the prevention and treatment of occupational tumors.
