Surveillance of HIV transmitted drug resistance
- Author:
LI Hanping
;
LI Lin
;
LI Jingyun
- Publication Type:Review
- Keywords:
Transmitted drug resistance;
surveillance;
drug resistance mutations;
fitness
- From:
China Tropical Medicine
2024;24(1):6-
- CountryChina
- Language:Chinese
-
Abstract:
Human immunodeficiency virus (HIV) transmitted drug resistance (TDR) means the infection of HIV drug-resistant strains, which are detected in patients without a history of exposure to antiretroviral (ARV) drugs. TDR has the potential to reverse the effectiveness of first-line antiretroviral therapy, pre-exposure prophylaxis (PrEP), and post-exposure prophylaxis (PEP), and is the practical major threat to the realization of the targets for HIV prevention and control. The changes in fitness of HIV DR strains are the basic biological factor challenging the risk of its transmission, and related to the selection of the survey population, the determination of the time span between diagnosis of HIV infection and testing of DR, and the application of DR test assay. The integrated definition and interpretation of surveillance drug resistance mutations (SDRMs) is the key to obtaining accurate surveillance results. This article reviews the recent progress in research on the fitness of HIV DR strains, identification of SDRMs, and the selection of surveillance population. It also proposes key areas for TDR monitoring in China, including the development of SDRMs list tailored to the characteristics of Chinese strains, high-resolution sequencing to accurately identify mixed base pairs, and the standardization of TDR monitoring. These efforts will provide scientific support for accurate TDR monitoring results and effective containment of the transmission of drug-resistant strains.
- Full text:20250109101048630312.Surveillance of HIV transmitted drug resistance.pdf
