Effect of safflower yellow injection on the pharmacokinetics and anticoagulation of aspirin
10.11665/j.issn.1000-5048.2024031902
- VernacularTitle:注射用红花黄色素对阿司匹林的药动学和抗凝作用的影响研究
- Author:
Dandan SHEN
1
;
Zhonghui YANG
;
Ji HUANG
;
Yingfei OU
;
Yunlong SHAN
Author Information
1. 太仓市第一人民医院, 苏州大学附属太仓医院, 太仓215400
- Publication Type:Journal Article
- Keywords:
aspirin / safflower yellow injection / drug interaction / salicylic acid
- From:
Journal of China Pharmaceutical University
2024;55(6):795-800
- CountryChina
- Language:Chinese
-
Abstract:
This article explores the interaction between aspirin and safflower yellow injection from the perspective of pharmacokinetics, combined with pharmacological indicators such as anticoagulation. Quantitative HPLC analysis was performed for the detection of salicylic acid in plasma samples, and the pharmacokinetic effects of aspirin in combination with safflower yellow injection on aspirin’s hydrolyzed product salicylic acid was evaluated. Thromboxane B2 (TXB2) and 6-keto prostaglandin F1 in plasma were determined using enzyme-linked immunosorbent assay and fully automated biochemical analyzer α (6-keto-PGF1) α）, and the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), and serum creatinine (Scr) were tested to evaluate the anticoagulant effect and safety indicators after long-term combined use of the two drugs, including liver and kidney function and cardiac pathological examination. The results showed that, compared with the aspirin group, there was no significant difference (P>0.05) in the plasma pharmacokinetic parameters of rats with combined use of safflower yellow injection. In addition, the plasma TXB2 in the combination group was significantly reduced compared to the aspirin group (P<0.01), yet with no significant difference for 6-keto-PGF1 α (P>0.05). There was no statistically significant difference in the levels of serum BUN, Scr, AST, and ALT between the two groups before and after treatment (P>0.05). These results suggest that the combination of aspirin and safflower yellow injection does not cause significant change in the blood concentration of salicylic acid. It does not affect the antiplatelet effect of aspirin.
