Effect of external mechanical forces on the crystallographic solid form and dissolution rate of traditional Chinese medicine extracts——taking Ligustrum lucidum extract as an example
10.11665/j.issn.1000-5048.2023122902
- VernacularTitle:机械外力对中药提取物晶体学固态形式及溶出速率的影响研究——以女贞子提取物为例
- Author:
Linlin LIANG
;
Zhiwei WANG
;
Xiaoshuang HE
;
Weili HENG
;
Shuai QIAN
;
Yuan GAO
;
Jianjun ZHANG
;
Yuanfeng WEI
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine extracts / crystallographic solid form / dissolution rate / quality of traditional Chinese medicine preparations
- From:
Journal of China Pharmaceutical University
2024;55(6):767-774
- CountryChina
- Language:Chinese
-
Abstract:
Taking the Ligustrum lucidum extract as an example, this study investigated the influence of external mechanical forces under different processing conditions on the crystallographic solid form and the key parameter of drug dissolution rate, so as to provide guidance for the preparation and quality control of traditional Chinese medicine preparations. Under different pulverization and tableting conditions, the change of crystallographic solid form of L. lucidum extract was observed by polarizing light microscope. Meanwhile, the effect of this change on the dissolution rate was investigated, and the mathematical relationship between crystal content and dissolution rate was analyzed. The results showed that the process of ball milling and tableting had a significant impact on the crystallographic solid form of L. lucidum extract. The amorphous extract displayed crystal transformation, which induced a significant decline in dissolution rate. Further studies revealed that there was a negative linear relationship between crystal content and dissolution rate. The results of this study indicated that the crystallographic solid form transformation of traditional Chinese medicine extracts might occur during the preparation process, which may cause potential risks to the quality of traditional Chinese medicine preparations. It is suggested that we should pay attention to and strengthen the investigation of the crystallographic solid form during the preparation process, so as to guarantee the safety, effectiveness, and quality controllability of traditional Chinese medicine preparations.
