Effects of pharmaceutical excipients on drug supersaturation in amorphous solid dispersions
10.11665/j.issn.1000-5048.2023123001
- VernacularTitle:药用辅料对无定形固体分散体中药物过饱和的影响
- Author:
Huijian WANG
1
;
Yanfei WANG
;
Wei SU
;
Qiang FU
Author Information
1. 沈阳药科大学机构无涯创新学院, 沈阳110016
- Publication Type:Journal Article
- Keywords:
pharmaceutical excipients / amorphous solid dispersion / drug supersaturated solution
- From:
Journal of China Pharmaceutical University
2024;55(6):725-733
- CountryChina
- Language:Chinese
-
Abstract:
Using the amorphous solid dispersion (ASD) technology, poorly water-soluble drugs can be formulated into high-energy amorphous forms. After oral administration, a kinetic supersaturated solution is formed in the gastrointestinal tract, and oral bioavailability is thus effectively improved. As important components of ASDs, pharmaceutical excipients affect the supersaturation of ASDs. Therefore, it is significant to clarify the effects of various types of pharmaceutical excipients on the supersaturated solutions for the development of ASDs. This paper reviews the effects of polymers, small-molecule excipients, and porous materials on the supersaturated solutions formed after dissoptlution of ASD with an emphasis on the mechanisms of various types of pharmaceutical excipients on the supersaturated solutions, providing theoretical guidance for the rational selection of medicinal excipients in the development of ASDs.
