Optimization of Extraction Process of Gastropathy Oral Thick Paste 1 by Orthogonal Design Based on Analytic Hierarchy Process Method–Entropy Weight Method-Independent Weight Method
10.13748/j.cnki.issn1007-7693.20230924
- VernacularTitle:基于层次分析法-熵权法-独立性权法结合正交设计法优选胃病1号提取工艺
- Author:
LIU Qi
1
;
ZHANG Yue
1
;
SHENG Yan
2
;
HU Yunli
1
;
JIANG Huijie
1
;
SHEN Kaifeng
1
;
JIANG Yan
1
;
CHEN Chengshou
3
;
ZHOU Danying
1
Author Information
1. Zhejiang Institute of Traditional Chinese Medicine Co., Ltd., Hangzhou 310023, China
2. Zhejiang Provincial Drug and Cosmetics Evaluation Center, Hangzhou 310012, China
3. Zhejiang Weibao Pharmaceutical Co., Ltd., Hangzhou 310013, China
- Publication Type:Journal Article
- Keywords:
:gastropathy oral thick paste 1 / extraction technology / analytic hierarchy process-entropy weight method- independent weight method
- From:
Chinese Journal of Modern Applied Pharmacy
2023;40(21):2998-3004
- CountryChina
- Language:Chinese
-
Abstract:
Abstract:OBJECTIVE To determine the index weight, optimize the extraction process of gastropathy oral thick paste 1. METHODS Taking the amount of water added, extraction time and extraction times as factors, depend on the single factor experiment, L9(34) orthogonal table was selected to design the experiment. The content of chlorogenic acid was determined by HPLC and the content of total flavonoids content was determined by ultraviolet spectrophotometry. With the above two contents plus the yield of dry extractum as the evaluation index, the weights were assigned based on the analytic hierarchy process, entropy weight method and independence weight method, and the extraction process was optimized by orthogonal experimental design. RESULTS Multi-index scoring was more scientific and reasonable, and the final optimal extraction conditions for gastropathy oral thick paste 1 were as follows: add 8 times the amount of water, extract twice and 0.5 h for each time. CONCLUSION The optimized extraction process using analytic hierarchy process, entropy weight method and independence weight method is reasonable, feasible, stable, and reproducible, which is suitable for the preparation of gastropathy oral thick paste 1, providing reference for subsequent research and development.
