Study on Synthesis and Antitumor Activity of Novel Bacteriochlorin Derivative
DOI:10.13748/j.cnki.issn1007-7693.20230430
- VernacularTitle:新型细菌卟吩类衍生物的合成及抗肿瘤活性研究
- Author:
LYU Zhiqing
1
;
CHEN Zhenliang
1
Author Information
1. Zhejiang Hisun Pharmaceutical Co., Ltd., Taizhou 318000, China
- Publication Type:Journal Article
- Keywords:
bacteriochlorin / synthesis / photodynamic therapy / antitumor
- From:
Chinese Journal of Modern Applied Pharmacy
2023;40(21):2964-2971
- CountryChina
- Language:Chinese
-
Abstract:
Abstract: OBJECTIVE To design and synthesize a novel bacteriochlorin derivative and study its antitumor effect. METHODS The target compound was synthesized from bacteriochlorin derivative via reduction, bromination after reacted with methyl 2-[4-(hydroxymethyl)phenoxy]acetate via etherification and hydrolysis. NCI-H460 BALB/c nude mice model was used to detect the distribution of drugs in various tissues, the antitumor effect of the target compound was studied by photodynamic therapy. RESULTS A novel bacteriochlorin derivative was synthesized, and structure was characterized by 1H-NMR, 13C-NMR, MS and UV. The target compound expressed fine distribution in tissues, and it had a great inhibit effect on the growth of tumor cells. CONCLUSION After introducing hydrophilic group into the structure of bacteriochlorin derivative, the tissue selectivity and antitumor effect has been improved, which is worthy of further study.
