Lymphocytopenia associated with leucocyte-reduced platelet apheresis: form concern, wane to concern again

VernacularTitle:少白细胞血小板单采相关淋巴细胞减少——从关切、淡化到再度关切
Author: Yongjian GUO ^{1
,

2} ; Limei WANG ¹ ; Jia ZENG ¹
Author Information

1. Fujian Provincial Blood Centre, Fuzhou 350004, China
2. Sub-Committee of Blood Standards, National Committee of Health Standard
Publication Type:Journal Article
Keywords: lymphocytopenia; platelet apheresis; adverse reactions to blood donation
From: Chinese Journal of Blood Transfusion 2024;37(12):1450-1455
CountryChina
Language:Chinese
Abstract: [Abstract] In the early stage of the application of platelet apheresis technology, there was a concern that high-frequency platelet apheresis might lead to the risk of lymphocyte depletion in blood donors. With the advances in platelet apheresis technology and improvements in collection purity and efficiency, this concern was waning. In recent years, with the wide application of leucocyte-reduced platelets apheresis, this issue has once again become a concern and research hotspot in the international blood transfusion research field. We briefly review this concern and focus on the research progress in recent years and put forward some suggestions to reduce this potential risk and of further research.