Clinical Comprehensive Evaluation of Cefazolin and Cefuroxime in Pediatric Clean Surgical Prophylaxis
DOI:10.13748/j.cnki.issn1007-7693.20232566
- VernacularTitle:头孢唑林与头孢呋辛用于儿童清洁手术预防用药的临床综合评价
- Author:
XIE Xinhe
1
,
2
;
LIU Runhong
3
;
HOU Yuexiu
4
;
ZHAO Ruiling
4
,
5
,
6
Author Information
1. Department of Pharmacy, General Hospital of Taiyuan Iron &
2. Steel(Group) Go., Ltd., Taiyuan 030008, China
3. Department of Pharmacy, The Yangpu East Hospital of Shanghai, Shanghai 200438, China
4. College of Pharmacy, Shanxi Medical University, Taiyuan 030001, China
5. 4. Office of Drug Trial Institution, Shanxi Children'
6. s Hospital, Taiyuan 030013, China
- Publication Type:Journal Article
- Keywords:
cefazolin / cefuroxime / children / clean surgery / clinical comprehensive evaluation
- From:
Chinese Journal of Modern Applied Pharmacy
2023;40(22):3129-3135
- CountryChina
- Language:Chinese
-
Abstract:
Abstract:OBJECTIVE To carry out clinical comprehensive evaluation of prophylactic drugs for clean surgery(type I incision) in children, and to promote the rational use of antibiotics during perioperative period. METHODS According to the Guidelines for the Management of Comprehensive Clinical Evaluation of Drugs(trial edition of 2021), the clinical comprehensive evaluation system of prophylactic drugs for clean surgery(type I incision) was established by using the methods of literature research, brainstorming, expert interview and Delphi, and the evaluation evidence was collected to carry out the comprehensive evaluation of multi-dimensional and multi-level evidence. RESULTS The clinical comprehensive evaluation system was constructed, including 5 first-class indicators(safety, effectiveness, economy, suitability, and accessibility), 11 second-class indicators and 30 third-class indicators. The clinical comprehensive evaluation score of cefazolin was 86.09, and that of cefuroxime was 81.86. The former was better than the latter in safety, effectiveness, economy and suitability, while the latter was better than the former in accessibility. CONCLUSION The clinical comprehensive evaluation of prophylactic drugs for clean surgery(type I incision) in children constructed in this study is scientific, and the results provides a basis for the selection of antibiotics for clean surgery(type I incision) in hospital
