Role of neuroimmune communication via the gut-brain axis in the pathogenesis of hepatic encephalopathy
- VernacularTitle:肠-脑轴神经免疫通信在肝性脑病发病机制中的作用
- Author:
Yong LIN
1
;
Jiongfen LI
1
;
Feiyan LI
1
;
Yuanqin DU
1
;
Meiyan LIU
1
;
Minggang WANG
2
;
Fuli LONG
2
;
Na WANG
2
;
Dewen MAO
2
Author Information
- Publication Type:Review
- Keywords: Hepatic Encephalopathy; Neuroimmunomodulation; Gastrointestinal Microbiome
- From: Journal of Clinical Hepatology 2024;40(12):2518-2523
- CountryChina
- Language:Chinese
- Abstract: Hepatic encephalopathy （HE） is a common severe liver disease syndrome in clinical practice and is one of the critical and severe diseases in internal medicine， and more than half of liver failure patients diagnosed with overt HE have a survival time of less than 1 year. A comprehensive analysis of the complex pathogenesis of HE and the development of diagnosis and treatment regimens based on evidence-based medicine are of great importance for alleviating high medical resource consumption， high medical expenses， and high incidence and mortality rates in clinical practice. The latest studies have shown that the intestinal tract and the central nervous system can perform bidirectional continuous interaction and signal transmission and regulate the function of inflammation signals， molecules， cells， and organs， which is known as neuroimmune communication and is highly consistent with the main pathological features of HE. With a focus on the mechanism of neuroimmune communication in HE， this article reviews the association between inflammation signal transduction via the gut-brain axis and neurotransmitter regulation and its role in neuroimmune communication in HE， which provides new ideas for the clinical diagnosis and treatment of HE and the research and development of related drugs.
