Mechanism of action of disulfidptosis in nonalcoholic fatty liver disease
- VernacularTitle:双硫死亡在非酒精性脂肪性肝病中的作用机制
- Author:
Lisha YAN
1
;
Yu CHEN
1
;
Xueshi WANG
1
;
Xianmin FENG
2
;
Jie SUN
2
Author Information
- Publication Type:Review
- Keywords: Non-alcoholic Fatty Liver Disease; Disulfidptosis; Pathologic Processes
- From: Journal of Clinical Hepatology 2024;40(12):2513-2517
- CountryChina
- Language:Chinese
- Abstract: Disulfidptosis is a novel pattern of cell death caused by disulfide stress and inadequate NADPH. Nonalcoholic fatty liver disease （NAFLD） is a group of metabolic diseases with the main pathological feature of fatty infiltration， and it is closely associated with insulin resistance and genetic susceptibility. Currently， the latest studies have shown that disulfide stress caused by disulfidptosis can result in hepatocyte death， thereby accelerating the progression of NAFLD. This article summarizes and analyzes the latest studies on disulfidptosis in NAFLD， in order to explore the application of disulfidptosis in NAFLD and provide new ideas for the prevention and treatment of NAFLD.
