Exploring the Application of "Cleaning Spleen and Restoring Defensive Qi" Method in Treatment of Pancreatic Cancer based on Neutrophil Extracellular Traps Abnormal Accumulation
10.13288/j.11-2166/r.2025.01.006
- VernacularTitle:基于中性粒细胞胞外诱捕网异常堆积探讨清脾复卫法在胰腺癌治疗中的应用
- Author:
Chuanlong ZHANG
1
;
Mengqi GAO
2
;
Yi LI
3
;
Xiaochen JIANG
3
;
Songting SHOU
3
;
Bo PANG
3
;
Baojin HUA
3
Author Information
1. Beijing Friendship Hospital，Capital Medical University，Beijing，100050
2. Wangjing Hospital of China Academy of Chinese Medical Sciences
3. Guang'anmen Hospital，China Academy of Chinese Medical Sciences
- Publication Type:Journal Article
- Keywords:
pancreatic cancer;
neutrophil extracellular traps;
defensive qi stagnation;
cleaning spleen and restoring defensive qi
- From:
Journal of Traditional Chinese Medicine
2025;66(1):30-33
- CountryChina
- Language:Chinese
-
Abstract:
The abnormal accumulation of neutrophil extracellular traps （NETs） can promote the initiation and progression of pancreatic cancer， which is considered a potential therapeutic target for this disease. The Miraculous Pivot·Inquiry About Statement （《灵枢·口问》） have recorded the concept of "defensive qi stagnation". Based on the recognition that the function of defensive qi is similar to the immune function of neutrophils， and combining traditional Chinese medicine theory with clinical practice， it is proposed that the abnormal accumulation of NETs may be a pathological product of "defensive qi stagnation"， with the spleen being the critical site of pathology. Further exploring the application strategy of cleaning spleen and restoring defensive qi method in pancreatic cancer treatment， it is proposed to employ three approaches such as dredging method to eliminate spleen stagnation and inhibit pancreatic cancer proliferation， cleaning method to remove spleen dampness and suppress the inflammatory micro-environment， and tonifying method to strengthen Weiqi and to improve the immune microenvironment， which aims to provide new insights for the clinical treatment of pancreatic cancer with traditional Chinese medicine.
