Signaling Pathways Related to Polycystic Ovary Syndrome and Regulation by Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20241130
- VernacularTitle:多囊卵巢综合征相关信号通路及其中医药调控研究进展
- Author:
Manman YAO
1
;
Liya MA
1
;
Dawei ZHANG
2
;
Xuelin ZHANG
2
;
Xuan ZHOU
2
;
Yu TANG
1
Author Information
1. Henan University of Chinese Medicine， Zhengzhou 450046， China
2. The Third Affiliated Hospital of Henan University of Chinese Medicine， Zhengzhou 450008， China
- Publication Type:Journal Article
- Keywords:
polycystic ovary syndrome;
traditional Chinese medicine;
research progress;
signaling pathway;
mechanism of action
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(3):301-312
- CountryChina
- Language:Chinese
-
Abstract:
Polycystic ovary syndrome （PCOS） is one of the most prevalent gynecological diseases， and its incidence is increasing year by year， seriously affecting the physical and mental health of female patients. The pathogenesis of this disease is complex and has not been fully clarified. At present， PCOS is mainly treated by Western medicine， which， however， has poor efficacy and induces various adverse reactions. Therefore， developing safe and effective therapies has become a difficult problem that needs to be solved. Studies have confirmed that traditional Chinese medicine （TCM） can regulate phosphatidylinositol 3-kinase/protein kinase B（PI3K/Akt）， mitogen-activated protein kinase/extracellular signal-regulated kinase （MAPK/ERK）， Toll-like receptor 4/nuclear factor-κB （TLR4/NF-κB）， transforming growth factor-β （TGF-β）/Smads， secreted glycoprotein/β-catenin （Wnt/β-catenin）， adenosine monophosphate-activated protein kinase （AMPK）， and advanced glycation endproduct/receptor for advanced glycation endproducts （AGE/RAGE） signaling pathways to ameliorate insulin resistance， inhibit inflammation and oxidative stress， regulate endocrine hormone disorders， and intervene in apoptosis and autophagy， thus alleviating the symptoms， slowing down the disease progression， and improving the ovarian function. The treatment of PCOS with TCM has demonstrated definite effects and high safety. Therefore， exploring this disease from cellular and molecular perspectives can provide a theoretical basis for its clinical treatment and new drug development. However， there is a lack of systematic reviews on the modulation of relevant signaling pathways by TCM in the treatment of PCOS. This article reviews the research progress in the treatment of PCOS with the active ingredients and compound prescriptions of TCM by regulating relevant signaling pathways in recent years， with the aim of providing evidence to support the promotion of TCM for treating PCOS in the future.
