Traditional Chinese Medicine Treats Diabetic Nephropathy via Pathways Related to Pyroptosis： A Review
10.13422/j.cnki.syfjx.20242298
- VernacularTitle:基于细胞焦亡相关通路探讨中医药治疗糖尿病肾病的研究进展
- Author:
Jintao SHI
1
;
Zhiyi ZHANG
1
;
Yunfei WEI
1
;
Jiarui HAN
1
Author Information
1. The Second Clinical Medical School，Henan University of Chinese Medicine， Zhengzhou 450002，China
- Publication Type:Journal Article
- Keywords:
diabetic kidney disease;
pyroptosis;
signaling pathway;
traditional Chinese medicine;
mechanism research
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(3):290-300
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic kidney disease （DKD）， one of the leading causes of end-stage renal disease， shows increasing prevalence and mortality， seriously affecting the physical and mental health of patients. As a crucial link in the occurrence and development of DKD， pyroptosis can lead to kidney cell injury and inflammation through the abnormal activation of reactive oxygen species （ROS）/thioredoxin-interacting protein （TXNIP）/NOD-like receptor protein 3 （NLRP3）， Toll-like receptor 4 （TLR4）/nuclear factor-κB （NF-κB）/NLRP3， nuclear factor erythroid 2-related factor 2 （Nrf2）/heme oxygenase-1 （HO-1）， mitogen-activated protein kinase （MAPK）/NLRP3， and hypoxia-inducible factor-1α （HIF-1α）/NLRP3 signaling pathways， which accelerate the progression of DKD. In recent years， traditional Chinese medicine （TCM） has demonstrated definite efficacy in the treatment of DKD via multiple targets and pathways. Studies have shown that various TCM active components， including glycosides， flavonoids， polyphenols， terpenoids， and alkaloids， as well as TCM compound prescriptions for clearing heat and detoxifying， tonifying deficiency and consolidating root， and eliminating stasis and descending turbidity， can target relevant signaling pathways to inhibit pyroptosis and intervene in the development of DKD， providing new possibilities for precision treatment of DKD. This article systematically reviews the relevant pathways of pyroptosis and summarizes the research achievements and mechanisms of TCM active components and compound prescriptions in the treatment of DKD via pyroptosis in recent years. This review aims to provide new directions and ideas for the treatment and research of DKD with TCM and promote the modernization and development of TCM.
